Gómez Macías G S, Pérez Saucedo J E, Cardona Huerta S, Garza Montemayor M, Villarreal Garza C, García Hernández I
Department of Pathology, Hospital San José of Tecnológico de Monterrey, Mexico.
Department of Pathology, Hospital San José of Tecnológico de Monterrey, Mexico.
Int J Surg Case Rep. 2016;25:33-6. doi: 10.1016/j.ijscr.2016.05.056. Epub 2016 Jun 3.
Invasive lobular carcinoma is the second most common histological type of breast carcinoma, accounting for approximately 5%-15% of all invasive breast cancers. The extracellular mucin secretion is by default a feature of ductal carcinoma. Only four cases of infiltrative lobular carcinoma with extracellular mucin have been report.
A 60 year old female asymptomatic patient with palpable breast mass and architectural distortion by mammography on external upper quadrant of the right breast was diagnosed as invasive lobular carcinoma with extracellular mucin in the resection, confirmed with immunohistochemistry markers.
Previous report in the literature of four cases of Invasive lobular carcinoma of breast with extracellular mucin, all of them sharing the same histologic features: the presence of extracellular and intracellular mucin with appearance of infiltrates lobular carcinoma with signet ring cells and "Indian files".
It is important to know that extracellular mucin production is not exclusive of ductal lesions and keep in mind the lobular carcinomas with extracellular mucin as a differential diagnosis.
浸润性小叶癌是乳腺癌第二常见的组织学类型，约占所有浸润性乳腺癌的5%-15%。细胞外黏液分泌通常是导管癌的特征。仅报道过4例伴有细胞外黏液的浸润性小叶癌。
一名60岁无症状女性患者，右乳外上象限可触及乳腺肿块，乳腺钼靶显示结构紊乱，切除术后诊断为伴有细胞外黏液的浸润性小叶癌，经免疫组化标记物证实。
文献中先前报道的4例伴有细胞外黏液的乳腺浸润性小叶癌，均具有相同的组织学特征：存在细胞外和细胞内黏液，伴有印戒细胞和“印度兵样排列”的浸润性小叶癌表现。
重要的是要知道细胞外黏液产生并非导管病变所特有，并将伴有细胞外黏液的小叶癌作为鉴别诊断加以考虑。
