Rosa Marilin, Mohammadi Amir, Masood Shahla
Department of Pathology and Laboratory Medicine, University of Florida, Jacksonville, Florida 32209, USA.
Pathol Int. 2009 Jun;59(6):405-9. doi: 10.1111/j.1440-1827.2009.02385.x.
The presence of mucin in infiltrating lobular carcinomas has been described as occurring exclusively in an intracytoplasmic location. To the best of the authors' knowledge, infiltrating lobular carcinoma displaying extracellular mucin has not been described in the literature. Herein is presented a case of lobular carcinoma with extracellular mucin in a 60-year-old female patient, who also had a contralateral ductal carcinoma of the cribriform type. Histologically the tumor had the classical appearance of infiltrating lobular carcinoma with signet ring cells and 'Indian file' infiltration of the stroma as well as pools of extracellular mucin. It is of great importance to appropriately classify breast carcinomas as ductal or lobular in origin due to the different treatment, prognosis, and clinical behavior of these lesions. The present finding opens the door for discussion of the current knowledge concerning histological variants of lobular carcinoma and should alert pathologists to the fact that the presence of extracellular mucin in an otherwise classical infiltrating lobular carcinoma does not preclude this diagnosis.
浸润性小叶癌中黏液的存在已被描述为仅发生在细胞质内。据作者所知，文献中尚未描述过显示细胞外黏液的浸润性小叶癌。本文报告一例60岁女性患者的小叶癌伴有细胞外黏液，该患者还患有对侧筛状型导管癌。组织学上，肿瘤具有浸润性小叶癌的典型表现，有印戒细胞和间质的“单行”浸润以及细胞外黏液池。由于这些病变的治疗、预后和临床行为不同，正确将乳腺癌分类为导管起源或小叶起源非常重要。目前的发现为讨论小叶癌的组织学变异的现有知识打开了大门，并应提醒病理学家注意，在其他方面为典型浸润性小叶癌的情况下，细胞外黏液的存在并不排除该诊断。
