Theaker J M, Gatter K C, Puddle J
University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, UK.
Histopathology. 1988 Aug;13(2):171-9. doi: 10.1111/j.1365-2559.1988.tb02022.x.
Specimens of normal peripheral nerve and a series of peripheral nerve lesions have been immunostained with three different anti-epithelial membrane antigen (EMA) monoclonal antibodies. Sites of EMA immunoreactivity have been confirmed within perineurial cells of peripheral nerve, noted within the capsule of Schwannomas and palisaded encapsulated neuromas, and also detected with traumatic neuromas and plexiform neurofibromas. No expression was detected within simple neurofibromas, diffuse neurofibromas or within malignant Schwannomas. These sites of EMA expression concur with the suggested involvement of perineurial cells in the formation of the particular lesions. The relationship between EMA expression by the perineurium and the piaarachnoid membrane is discussed.
正常周围神经标本以及一系列周围神经病变标本已用三种不同的抗上皮膜抗原（EMA）单克隆抗体进行免疫染色。已证实在周围神经的神经束膜细胞内存在EMA免疫反应性位点，在施万瘤和栅栏状包膜神经瘤的包膜内也有发现，在创伤性神经瘤和丛状神经纤维瘤中也检测到了该位点。在单纯性神经纤维瘤、弥漫性神经纤维瘤或恶性施万瘤内未检测到表达。这些EMA表达位点与提示神经束膜细胞参与特定病变形成的观点一致。讨论了神经束膜与软脑膜蛛网膜膜之间EMA表达的关系。
