红细胞输注对胃癌患者血浆铁调素和生长分化因子15的影响：一项前瞻性研究。
The effect of red blood cell transfusion on plasma hepcidin and growth differentiation factor 15 in gastric cancer patients: a prospective study.
作者信息
Liu Jingfu, Chen Shan, Ye Xianren
机构信息
Department of Blood Transfusion, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou 350014, China.
Fujian Provincial Key Laboratory of Tumor Biotherapy, Fuzhou 350014, China.
出版信息
Ann Transl Med. 2019 Sep;7(18):466. doi: 10.21037/atm.2019.08.33.
BACKGROUND
Hepcidin and growth differentiation factor 15 (GDF-15) have been reported to be highly expressed in various cancers. Serum hepcidin and GDF-15 levels were demonstrated to be potential prognostic markers in cancers. This study aims to evaluate the effect of red blood cell (RBC) transfusion on plasma hepcidin and GDF-15 in gastric cancer patients.
METHODS
In this prospective study, 40 patients with gastric cancer were eligible for this study. Peripheral blood samples were obtained before and within 24 h after RBC transfusion. A routine blood test was performed before transfusion and within 24 h post-transfusion. Plasma hepcidin, GDF-15, interleukin 6 (IL-6) and erythropoietin were determined by ELISA.
RESULTS
In patients with metastasis, plasma hepcidin (P=0.02), and GDF-15 (P=0.01) levels were higher than without metastasis. Plasma hepcidin was increased after RBC transfusion (P=0.001), while plasma erythropoietin was decreased after transfusion (P=0.03). However, RBC transfusion did not affect plasma GDF-15 (P=0.32) and IL-6 (P=0.12). The effect of RBC transfusion on variables did not differ between metastatic and non-metastatic patients. The mean percentage change of hepcidin in transfusion volume 4 unit (U) was more than 2 U.
CONCLUSIONS
RBC transfusion could increase plasma hepcidin and have no effect on plasma GDF-15 in gastric patients.
背景
已有报道称，铁调素和生长分化因子15（GDF - 15）在多种癌症中高表达。血清铁调素和GDF - 15水平被证明是癌症潜在的预后标志物。本研究旨在评估红细胞（RBC）输血对胃癌患者血浆铁调素和GDF - 15的影响。
方法
在这项前瞻性研究中，40例胃癌患者符合本研究条件。在RBC输血前及输血后24小时内采集外周血样本。输血前及输血后24小时内进行血常规检查。采用酶联免疫吸附测定法（ELISA）测定血浆铁调素、GDF - 15、白细胞介素6（IL - 6）和促红细胞生成素。
结果
发生转移的患者血浆铁调素（P = 0.02）和GDF - 15（P = 0.01）水平高于未发生转移的患者。RBC输血后血浆铁调素升高（P = 0.001），而输血后血浆促红细胞生成素降低（P = 0.03）。然而，RBC输血不影响血浆GDF - 15（P = 0.32）和IL - 6（P = 0.12）。RBC输血对各变量的影响在转移和未转移患者之间无差异。输血4单位（U）时铁调素的平均变化百分比大于2 U。
结论
RBC输血可使胃癌患者血浆铁调素升高，而对血浆GDF - 15无影响。
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