Escola de Medicina Veterinária e Zootecnia, Universidade Federal da Bahia, Salvador, Bahia, 40170-110, Brazil.
Instituto Federal de Educação, Ciência e Tecnologia do Sertão Pernambucano, Santa Maria da Boa Vista, Pernambuco, 56380-000, Brazil.
BMC Vet Res. 2019 Nov 8;15(1):401. doi: 10.1186/s12917-019-2151-y.
Dyslipidemias induce angiogenesis and accelerate the development and in vitro growth of breast tumors. The aim of this study was to assess the lipid and metabolic profile of female dogs with mammary carcinomas and their correlations with body condition score and degree of tumor malignancy, as well as to study the effect of dietary fish oil supplementation on these animals.
Overweight or obese dogs had more aggressive carcinomas and higher triglyceride (p = 0.0363), VLDL (p = 0.0181), albumin (p = 0.0188), globulin (p = 0.0145) and lactate (p = 0.0255) concentrations. There was no change in the lipid profile after supplementation with fish oil at any concentration. However, in relation to the metabolic profile, glucose (p = 0.0067), total protein (p = 0.0002) and globulin (p = 0.0002) concentrations were increased when 90% omega-3 fish oil was used as a dietary supplement.
Obese dogs showed altered lipid and metabolic profiles and more aggressive tumors, suggesting an important relationship between dyslipidemia and tumor aggressiveness. Supplementation with fish oil, rich in omega-3 fatty acids, may alter metabolic parameters in cancer patients.
脂代谢紊乱可诱导血管生成，并加速乳腺肿瘤的发展和体外生长。本研究旨在评估患有乳腺癌的雌性犬的血脂和代谢谱，并将其与体况评分和肿瘤恶性程度相关联，同时研究鱼油饮食补充对这些动物的影响。
超重或肥胖的犬具有侵袭性更强的癌和更高的甘油三酯（p=0.0363）、VLDL（p=0.0181）、白蛋白（p=0.0188）、球蛋白（p=0.0145）和乳酸（p=0.0255）浓度。在任何浓度下补充鱼油后，血脂谱均无变化。然而，在代谢谱方面，当使用 90%ω-3 鱼油作为膳食补充剂时，葡萄糖（p=0.0067）、总蛋白（p=0.0002）和球蛋白（p=0.0002）浓度增加。
肥胖犬表现出改变的脂质和代谢谱以及侵袭性更强的肿瘤，表明脂代谢紊乱与肿瘤侵袭性之间存在重要关系。富含 ω-3 脂肪酸的鱼油补充可能会改变癌症患者的代谢参数。
