从桉树叶子中提取的酪氨酸酶抑制剂。

Tyrosinase inhibitors from the leaves of Eucalyptus globulus.

机构信息

School of Pharmacy, Nanchang University, Nanchang 330006, PR China.

School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China.

出版信息

Fitoterapia. 2019 Nov;139:104418. doi: 10.1016/j.fitote.2019.104418. Epub 2019 Nov 5.

DOI:10.1016/j.fitote.2019.104418

PMID:31704262

Abstract

A new isoiphionane sesquiterpene, named (3S, 5S, 7S, 10R)-3, 11-dihydroxyisoiphion-4-one (1), two new phloroglucinol glycosides, named eucalglobuside A (2) and eucalglobuside B (3), along with 15 known compounds were isolated from the leaves of Eucalyptus globulus. Their structures were elucidated based on extensive spectroscopic analysis and in comparison with literature data. The absolute configuration of compound 1 was determined by ECD calculation. All isolates were evaluated their inhibitory activities against the mushroom tyrosinase. As a result, three sesquiterpenoids, 1, 5β, 11-dihydroxy-iphionan-4-one (5), and (-)-globulol (8), exhibited the most potent activities with IC values of 14.17 μM, 10.08 μM and 9.79 μM, respectively.

摘要

从蓝桉（Eucalyptus globulus）的叶子中分离得到了一种新的异佛尔酮倍半萜，命名为（3S, 5S, 7S, 10R）-3, 11-二羟基异佛尔酮-4-酮（1），两个新的松柏醛葡萄糖苷，命名为 eucalglobuside A（2）和 eucalglobuside B（3），以及 15 种已知化合物。根据广泛的光谱分析并与文献数据进行比较，确定了它们的结构。通过 ECD 计算确定了化合物 1 的绝对构型。所有分离物均评估了其对蘑菇酪氨酸酶的抑制活性。结果表明，三种倍半萜类化合物 1、5β、11-二羟基异佛尔酮-4-酮（5）和（-）-globulol（8）具有最强的活性，IC 值分别为 14.17 μM、10.08 μM 和 9.79 μM。