Ministry of Education Key Laboratory of Environmental Remediation and Ecosystem Health, Institution of Environmental Health, College of Environmental and Resource Sciences, Zhejiang University, Hangzhou, 310058, China.
Department of Epidemiology and Biostatistics, Zhejiang University School of Public Health, Hangzhou, 310058, China.
Environ Res. 2019 Dec;179(Pt B):108828. doi: 10.1016/j.envres.2019.108828. Epub 2019 Oct 18.
Polybrominated diphenyl ethers (PBDEs) were listed in the Stockholm Convention due to their persistent and toxic nature. In utero exposure to PBDEs might affect fetal development as it is sensitive when exposed to even low dose of xenobiotic substances during the pregnancy. In this study, a multi-centre human biomonitoring study of tri-to hexa-BDEs was conducted in three Chinese cities using 60 colostrum samples from local residents. The patterns and influencing factors, correlation with the birth outcome, and potential health risks during the breastfeeding of tri-to hexa-BDEs in the colostrum samples were assessed. The median concentration of tri-to hexa-BDEs was 9.1 (Interquartile range: 3.1-19.5) ng g lipid weight, and BDE-153 contributed 68% of the detected PBDEs. The PBDE levels were mostly associated with maternal age and drinking water sources, while correlations with other factors including weight gain, BMI, parity and the number of aborted pregnancies was not significant. The level of BDE-28 was positively correlated with the birth weight, while the BDE-99 was positively correlated with the head circumference, using multilinear regression. For the total hazard quotients, 60% of the infants have an estimated value higher than 1, showed potential chronic hazard for future development and possible adverse health effects to the babies from the exposure to PBDE congeners. Alternative food source seems to have a lower risk for neonates than the colostrum, but the advantages of breastfeeding undoubtedly outweigh the risks and potential adverse health effects caused by environmental PBDEs and other xenobiotic chemical exposure.
多溴二苯醚（PBDEs）因其持久性和毒性而被列入《斯德哥尔摩公约》。在子宫内接触 PBDEs 可能会影响胎儿发育，因为它在怀孕期间即使接触低剂量的外源性物质也很敏感。在这项研究中，在中国三个城市进行了一项多中心人类生物监测研究，使用当地居民的 60 份初乳样本，研究了三至六溴代二苯醚的浓度。评估了三至六溴代二苯醚在初乳样本中的模式和影响因素、与出生结局的相关性以及在母乳喂养期间的潜在健康风险。三至六溴代二苯醚的中位数浓度为 9.1（四分位距：3.1-19.5）ng g 脂质重量，BDE-153 占检测到的 PBDEs 的 68%。PBDE 水平主要与母亲年龄和饮用水源有关，而与体重增加、BMI、产次和流产次数等其他因素的相关性不显著。使用多元线性回归分析，BDE-28 水平与出生体重呈正相关，而 BDE-99 与头围呈正相关。对于总危害商数，60%的婴儿估计值高于 1，表明对未来发育存在潜在的慢性危害，以及婴儿可能因接触 PBDE 同系物而产生的不良健康影响。替代食物来源对新生儿的风险似乎低于初乳，但母乳喂养的优势无疑超过了环境 PBDEs 和其他外源性化学物质暴露所带来的风险和潜在的不良健康影响。
