Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University, Jeju, Republic of Korea.
Department of Disease Model Animal Research Center, College of Life Science and Technology, Heilongjiang Bayi Agricultural University, Daqing, P.R. China.
Anticancer Res. 2019 Nov;39(11):6115-6123. doi: 10.21873/anticanres.13819.
BACKGROUND/AIM: Colon cancer is the second most common deadliest malignancy in the world and better understanding of its underlying mechanisms is needed to improve clinical management. Natural plant extracts are gaining attention in the development of new therapeutic strategies against various cancer types. Shikonin is a naturally extracted naphthoquinone pigment with effects against cancer, including colon cancer.
In this study, we conducted a series of in vitro experiments to show the effects of Shikonin on colon cancer cell apoptosis. A colon cancer cell line with overexpression of peroxiredoxin V (PrxV) was constructed and the relationship of PrxV expression with Shikonin-induced cell apoptosis was investigated.
Shikonin induced colon cancer cell apoptosis via regulation of mammalian target of rapamycin signaling. Shikonin-induced cell apoptosis was abrogated by overexpression of PrxV.
According to the results obtained in this study, targeting PrxV may provide new insight for the successful management of colon cancer by inducing cell apoptosis.
背景/目的：结肠癌是世界上第二大最致命的恶性肿瘤，为了改善临床管理，需要更好地了解其潜在机制。天然植物提取物在开发针对各种癌症类型的新治疗策略方面受到关注。紫草素是一种天然提取的萘醌类色素，具有抗癌作用，包括结肠癌。
在这项研究中，我们进行了一系列体外实验，以显示紫草素对结肠癌细胞凋亡的影响。构建了过表达过氧化物酶 V（PrxV）的结肠癌细胞系，并研究了 PrxV 表达与紫草素诱导的细胞凋亡之间的关系。
紫草素通过调节哺乳动物雷帕霉素靶蛋白信号通路诱导结肠癌细胞凋亡。PrxV 的过表达阻断了紫草素诱导的细胞凋亡。
根据本研究的结果，靶向 PrxV 可能通过诱导细胞凋亡为成功管理结肠癌提供新的见解。
