Alvanos A, Rademacher S, Hoffmeister A, Seehofer D
Klinik für Viszeral‑, Transplantations- Thorax- und Gefäßchirurgie, Universitätsklinikum Leipzig, Liebigstr. 20, 04103, Leipzig, Deutschland.
Klinik für Gastroenterologie und Hepatologie, Universitätsklinikum Leipzig, Leipzig, Deutschland.
Chirurg. 2020 Jan;91(1):11-17. doi: 10.1007/s00104-019-01061-1.
Benign biliary diseases comprise entities, which present with very similar pathognomonic symptoms despite fundamental etiological differences. Obstructions of intrahepatic and extrahepatic bile ducts due to stones, tumors or parasites as well as stenoses and cystic alterations belong to the group of benign biliary diseases.
This article provides a systematic overview of the indications and differential treatment of benign biliary diseases with special emphasis on the surgical treatment.
The presented recommendations are in accordance with national and international guidelines, current scientific papers and expert opinions.
Essentially the surgical options for benign biliary diseases consist of revision, reconstruction through bilioenteric anastomosis, resection and complete organ replacement in the sense of liver transplantation. The location of the affected segment of the biliary tree, the symptoms, the progress of the disease and suspected malignancy essentially determine the level of escalation in the described treatment level scheme.
The treatment of benign biliary diseases is complex and requires achievement of unimpaired, unobstructed bile drainage. It serves the purpose of resolving cholestasis and thereby avoiding recurrent cholangitis and long-term complications, such as biliary cirrhosis and malignant transformation; however, in some cases of premalignant lesions of the bile ducts the strategy resembles cancer surgery, including resection of the affected tissue.
良性胆道疾病包含多种病症,尽管病因存在根本差异,但却有着极为相似的特征性症状。由结石、肿瘤或寄生虫以及狭窄和囊性改变引起的肝内和肝外胆管梗阻均属于良性胆道疾病范畴。
本文对良性胆道疾病的适应证及鉴别治疗进行系统概述,特别强调手术治疗。
所呈现的建议符合国家和国际指南、当前科学论文及专家意见。
本质上,良性胆道疾病的手术选择包括修复、通过胆肠吻合术进行重建、切除以及在肝移植意义上的完全器官置换。胆道树受累节段的位置、症状、疾病进展及疑似恶性肿瘤本质上决定了所述治疗方案中的升级水平。
良性胆道疾病的治疗较为复杂,需要实现胆汁引流通畅无阻。其目的在于解决胆汁淤积,从而避免复发性胆管炎及诸如胆汁性肝硬化和恶变等长期并发症;然而,在某些胆管癌前病变的情况下,治疗策略类似于癌症手术,包括切除受累组织。