2017 年原发性硬化性胆管炎临床指南。
Clinical guidelines for primary sclerosing cholangitis 2017.
机构信息
Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
Department of General Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
出版信息
J Gastroenterol. 2018 Sep;53(9):1006-1034. doi: 10.1007/s00535-018-1484-9. Epub 2018 Jun 27.
BACKGROUND
Primary sclerosing cholangitis (PSC) is relatively rare disease and pathogenesis and methods of treatments were still not established. Then, we had conducted the making clinical guidelines to manage patients with PSC based on the literature review and expert opinions. These clinical guidelines were made for the medical doctors on the management of PSC, except child case of PSC.
METHODS
We had employed modified Delphi method. The production committee decided guidelines, strength of recommendations and evidence level after reviewed literatures systematically, and The Expert panel evaluated those. The Scientific Committee of the Japan Biliary Association (JBA) evaluated revised guidelines, and the Public comments were collected on web site of JBA.
RESULTS
We had made 16 guidelines about epidemiology/pathophysiology, diagnostics, therapy and prognosis. Also, we had made both diagnostic and therapeutic flow chart.
CONCLUSIONS
We hope that these guidelines will contribute to the improvement and development of the medical care of PSC.
背景
原发性硬化性胆管炎（PSC）是一种相对罕见的疾病，其发病机制和治疗方法尚未确定。因此，我们根据文献回顾和专家意见制定了管理 PSC 患者的临床指南。这些临床指南是为管理 PSC 患者的医生制定的，不包括儿童 PSC 病例。
方法
我们采用改良 Delphi 法。制作委员会在系统审查文献后决定指南、推荐强度和证据水平，专家组对其进行评估。日本胆胰协会（JBA）的科学委员会对修订后的指南进行了评估，并在 JBA 的网站上收集了公众意见。
结果
我们制定了 16 条关于流行病学/发病机制、诊断、治疗和预后的指南。此外，我们还制定了诊断和治疗流程图。
结论
我们希望这些指南将有助于改善和发展 PSC 的医疗保健。
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