Neurobiology of Anxiety and Mood Disorders, University of Nantes, 98, rue Joseph Blanchart, 44100, Nantes, France.
Adv Exp Med Biol. 2019;1192:283-296. doi: 10.1007/978-981-32-9721-0_14.
Animal research in psychiatry suffers from a poor translational value. It is the same for all other disciplines. Our purpose in this chapter is therefore to highlight all the parameters that can lead to a non-reproducibility of interlaboratory experiments as well as intralaboratory. This is to point out the experimental parameters that are likely to lead to bias. Parameters are essentially: breeding conditions, animal strains, housing, handling, illumination, weather conditions, age, and the actual experimental conditions. Controlling these parameters is not enough if there is no consensus of the scientific community to implement them in a standardized way. However, it is possible to improve the translational concept by taking stock of what has been operational without forgetting to standardize as much as possible the essential parameters of behavioral research. Now there are calls to take a different approach to animal experimentation, by asking not what was controlled in an experiment, but what was ignored. This new school of thinking has been termed "therioepistemology"; the study of how knowledge is gained from animal research. The focus is on what's been ignored in an animal data set, why it's been ignored, and how it affects the model or experiment.
精神病学中的动物研究转化价值较低。其他所有学科也都存在这种情况。因此，本章的目的是强调所有可能导致实验室间和实验室内部实验不可重现的参数。这是为了指出可能导致偏差的实验参数。这些参数主要有：繁殖条件、动物品系、饲养、处理、光照、天气条件、年龄以及实际实验条件。如果科学界没有以标准化的方式来实施这些参数的共识，那么仅仅控制这些参数是不够的。然而，通过对已经运作的内容进行评估，同时尽可能标准化行为研究的基本参数，仍然可以提高转化概念。现在，人们呼吁采用一种不同的动物实验方法，不是询问在实验中控制了什么，而是询问忽略了什么。这种新的思维方式被称为“动物认识论”，即从动物研究中获取知识的研究。重点关注动物数据集被忽略的内容、被忽略的原因以及它如何影响模型或实验。
