Ilić Ivan, Cvetković Jana, Ilić Ratko, Cvetković Ljubiša, Milićević Aleksandar, Todorović Stefan, Ranđelović Pavle
Center for Pathology and Pathological Anatomy, University Clinical Center Niš, Faculty of Medicine, University of Niš, 18000 Niš, Serbia.
Department for Pathology, General Hospital Leskovac, 16000 Leskovac, Serbia.
Diagnostics (Basel). 2024 Mar 21;14(6):660. doi: 10.3390/diagnostics14060660.
The technical complexity of gene expression profiling in routine practice has necessitated the use of surrogate molecular classification of breast cancer, based on immunohistochemical analyses.
The aim of this study was to compare the differences between histological and molecular subtypes of invasive lobular carcinoma (ILC) of the breast, in order to be able to predict the behavior and prognosis of the disease, as well as to effectively determine therapy.
This study included 263 cases of breast ILC diagnosed over a seven-year period. The diagnosis of invasive lobular carcinoma is based on the characteristic growth pattern and phenotype of cancer cells with the respective subtypes: classic, alveolar, solid, tubulolobular, pleomorphic and mixed lobular type. The examined cases were divided into five groups according to molecular classification based on the expression of ER, PR, HER2 and Ki67 immunohistochemical markers.
It was found that the pleomorphic subtype occurred statistically significantly less often as the luminal A subtype compared to others ( = 0.00027), and the HER2-enriched subtype occurred statistically significantly more often in the pT4 stage ( = 0.024).
The results of this study significantly singled out the luminal A subtype, and among them classic ILC, as the subtype with the most favorable expression ratio of the investigated predictive/prognostic immunohistochemical markers.
在常规实践中，基因表达谱分析的技术复杂性使得基于免疫组织化学分析的乳腺癌替代分子分类成为必要。
本研究的目的是比较乳腺浸润性小叶癌（ILC）的组织学和分子亚型之间的差异，以便能够预测疾病的行为和预后，并有效确定治疗方案。
本研究纳入了7年间诊断的263例乳腺ILC病例。浸润性小叶癌的诊断基于癌细胞的特征性生长模式和表型以及各自的亚型：经典型、腺泡型、实体型、小管小叶型、多形型和混合小叶型。根据基于雌激素受体（ER）、孕激素受体（PR）、人表皮生长因子受体2（HER2）和Ki67免疫组化标记物表达的分子分类，将所检查的病例分为五组。
发现多形型亚型作为腔面A型亚型出现的频率在统计学上显著低于其他亚型（P = 0.00027），而HER2富集型亚型在pT4期出现的频率在统计学上显著更高（P = 0.024）。
本研究结果显著突出了腔面A型亚型，其中经典型ILC是所研究的预测/预后免疫组化标记物表达比例最有利的亚型。
