Metabolic Signalling Group, School Pharmacy and Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Perth, Western Australia, Australia.
Biochim Biophys Acta Rev Cancer. 2020 Jan;1873(1):188326. doi: 10.1016/j.bbcan.2019.188326. Epub 2019 Nov 9.
Pancreatic cancer is one of the leading determinants of global cancer mortality, and its incidence is predicted to increase, to become in 2030 the second most common cause of cancer-related death. Obesity and diabetes are recognized risk factors for the development of pancreatic cancer. In the last few decades an epidemic of diabetes and obesity has been spreading worldwide, forewarning an increase in incidence of pancreatic cancer. This review considers the most recent literature, covering the multiple molecular axis linking these three pathologies, aiming to draw a more comprehensive view of pancreatic cancer for a better theragnostic stratification of the population.
胰腺癌是全球癌症死亡率的主要决定因素之一，预计其发病率将会增加，到 2030 年将成为癌症相关死亡的第二大常见原因。肥胖症和糖尿病是胰腺癌发生的公认危险因素。在过去几十年中，糖尿病和肥胖症在全球范围内流行，预示着胰腺癌发病率的增加。本综述考虑了最新的文献，涵盖了将这三种病理联系在一起的多个分子轴，旨在更全面地了解胰腺癌，以便更好地对人群进行治疗分层。
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