Liaoning University of Traditional Chinese Medicine, Shenyang, China.
The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, China.
Front Endocrinol (Lausanne). 2024 Nov 7;15:1422071. doi: 10.3389/fendo.2024.1422071. eCollection 2024.
Obesity is becoming more widely acknowledged as a chronic illness that raises the risk of oncogenesis. This inquiry aimed to look into the correlation between cancer patient mortality and obesity, as measured by the weight-adjusted waist index (WWI).
We used continuous data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2018 as the benchmark, with a follow-up validity period of December 31, 2019. First, we assessed the correlation between WWI and the all-cause and cause-specific execution of cancer sufferers using multivariable Cox proportional hazards models. Second, a smoothed curve fit was utilized to examine the relationship between WWI and both cause-specific and all-cause mortality in cancer patients. Lastly, we analyzed the relationship between WWI and both cause-specific and all-cause mortality in cancer patients, to find out if this link held across the population subgroup evaluation and impact analyses were used as well during the last step.
With a median follow-up of 87.8 months, 1,547 (34.7%) of the 4,463 cancer patients had deceased. Among them, 508 (11.4%) succumbed to cancer, while 322 (7.2%) passed away due to cardiovascular disease. Multivariate Cox proportional hazards model of mortality among cancer patients revealed an all-cause mortality hazard ratio [HR=1.13; 95% CI (1.04, 1.23)] and cardiovascular mortality [HR=1.39; 95% CI (1.16, 1.67)]. Furthermore, for each unit increase in WWI, all-cause mortality was significantly higher in male cancer survivors than in female cancer survivors.
Our study reveals substantial correlations between WWI and all-cause and cardiovascular mortality in US cancer survivors, helping to identify cancer survivors at higher risk of death and thus potentially guiding targeted interventions.
肥胖已被广泛认为是一种增加致癌风险的慢性疾病。本研究旨在探讨体重调整腰围指数（WWI）与癌症患者死亡率之间的相关性。
我们以 1999 年至 2018 年国家健康和营养调查（NHANES）的连续数据为基准，随访截止日期为 2019 年 12 月 31 日。首先，我们使用多变量 Cox 比例风险模型评估了 WWI 与癌症患者全因和特定原因死亡率之间的相关性。其次，使用平滑曲线拟合来检查 WWI 与癌症患者特定原因和全因死亡率之间的关系。最后，我们分析了 WWI 与癌症患者特定原因和全因死亡率之间的关系，以确定这种关联在人群亚组评估中是否存在。在最后一步中，我们还使用了影响分析。
在中位随访 87.8 个月后，4463 例癌症患者中有 1547 例（34.7%）死亡。其中，508 例（11.4%）死于癌症，322 例（7.2%）死于心血管疾病。多变量 Cox 比例风险模型显示，癌症患者的全因死亡率风险比[HR=1.13；95%可信区间（1.04，1.23）]和心血管死亡率[HR=1.39；95%可信区间（1.16，1.67）]。此外，对于 WWI 的每单位增加，男性癌症幸存者的全因死亡率明显高于女性癌症幸存者。
我们的研究表明，WWI 与美国癌症幸存者的全因和心血管死亡率之间存在显著相关性，有助于确定死亡风险较高的癌症幸存者，从而可能指导有针对性的干预措施。
