López-Ramírez Yadira Lizethe, Aguilar-Velázquez José Alonso, López-Armenta Mauro, Ruiz-Hernández Mariana, Rangel-Villalobos Héctor
Laboratorio de Genética del Instituto de Ciencias Forenses (INCIFO), Tribunal Superior de Justicia de la Ciudad de México, México City, México.
Instituto de Investigación en Genética Molecular, Centro Universitario de la Ciénega, Universidad de Guadalajara (CUCiénega-UdeG), Av. Universidad #1115, Col. Paso Blanco, CP 47810, Ocotlán, Jalisco, México.
Int J Legal Med. 2020 Jan;134(1):199-202. doi: 10.1007/s00414-019-02183-1. Epub 2019 Nov 9.
We analyzed 307 Mexican-Mestizo (admixed) males from Mexico City with the Powerplex® Y23 system. The complete list of Y-STR haplotypes was uploaded into the YHRD database (accession number YA004275). The discriminatory capacity (98.70 %) and gene diversity (D = 99.99 %) were calculated, improving the haplotype diversity regarding previous studies in Mexico based on 17 Y-STRs and 12 Y-STRs. Haplogroup distribution assignment was inferred by means of two different online-available algorithms. The Native American Q* haplogroup was the most frequent (66.2 %), followed by the European R1b lineage (19.5 %). In addition, eight Eurasian (3.9%) and two African (6.6%) haplogroups were observed in this population sample from Mexico City. Interestingly, AMOVA test showed a low but significant differentiation among Mexican-Mestizos (Fst = 1.52%; p = 0.0000), suggesting that four population clusters allow to explain their genetic structure according to geographic criteria: north, west, center, and south.
我们使用Powerplex® Y23系统分析了来自墨西哥城的307名墨西哥梅斯蒂索（混血）男性。Y-STR单倍型的完整列表已上传至YHRD数据库（登录号YA004275）。计算了鉴别能力（98.70%）和基因多样性（D = 99.99%），与之前基于17个Y-STR和12个Y-STR的墨西哥研究相比，单倍型多样性有所提高。单倍群分布归属通过两种不同的在线算法推断得出。美洲原住民Q*单倍群最为常见（66.2%），其次是欧洲R1b谱系（19.5%）。此外，在这个来自墨西哥城的人群样本中还观察到8个欧亚单倍群（3.9%）和2个非洲单倍群（6.6%）。有趣的是，AMOVA检验显示墨西哥梅斯蒂索人之间存在低但显著的分化（Fst = 1.52%；p = 0.0000），这表明根据地理标准，四个种群聚类可以解释他们的遗传结构：北部、西部、中部和南部。
