Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Adv Exp Med Biol. 2019;1163:25-43. doi: 10.1007/978-981-13-8719-7_2.
Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level.
变构作用主要与单个蛋白质的构象和功能转变相关。所有动态蛋白质都是变构的。这一概念可以扩展到考虑构象扰动对细胞功能和疾病状态的影响。在本节中，我们将阐明变构作用如何控制生理活动并导致疾病，旨在提高人们对细胞水平疾病症状与分子水平特定异常变构作用之间联系的认识。
