Valentine J A, Scott J, West C R, St Hill C A
J Oral Pathol. 1985 Sep;14(8):654-65. doi: 10.1111/j.1600-0714.1985.tb00543.x.
Macroscopically normal tongues were examined from 161 necropsies. Two types of lingual epithelium were investigated by morphometry and the results were statistically analysed in relation to known levels of alcohol and tobacco usage in each case. Alcohol and tobacco were each associated with a reduction in epithelial thickness brought about by a reduction in the maturation layer due mainly to cell shrinkage. By contrast, the progenitor layer increased in size, due to hypertrophy rather than hyperplasia. Changes occurred in each type of epithelium and were more severe with alcohol. There was no significant interaction between alcohol and tobacco. The structural changes appeared to be non-specific reactions to local toxic effects of alcohol and tobacco. They could, if accompanied by equivalent functional decrements, indicate an increased vulnerability to carcinogens, whether or not these derive from alcoholic drinks or tobacco smoke.
从161例尸检中检查了宏观正常的舌头。通过形态计量学研究了两种类型的舌上皮，并根据每个病例已知的酒精和烟草使用水平对结果进行了统计分析。酒精和烟草均与上皮厚度的减少有关，这主要是由于细胞收缩导致成熟层减少所致。相比之下，祖细胞层由于肥大而非增生而增大。每种上皮类型都发生了变化，酒精导致的变化更严重。酒精和烟草之间没有显著的相互作用。结构变化似乎是对酒精和烟草局部毒性作用的非特异性反应。如果伴有同等程度的功能减退，它们可能表明对致癌物的易感性增加，无论这些致癌物是否来自酒精饮料或烟草烟雾。
