Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Adv Exp Med Biol. 2019;1163:107-139. doi: 10.1007/978-981-13-8719-7_6.
Allostery is considered one of the most direct and efficient ways to regulate biological macromolecule functions. Allostery is increasingly receiving attention in the field of drug discovery because of the unique advantages of allosteric modulators such as high selectivity and low toxicity. Because of technical breakthroughs in the allosteric studies, the understanding of the characteristics of allosteric entities such as allosteric proteins and their allosteric sites and modulators has made great strides. These features play a critical role in both the evolution of the allosteric concept and the prediction of allosteric interactions. In this chapter, we highlight the fundamental characteristics of allosteric proteins, allosteric sites, and allosteric modulators. Importantly, the applications of such principles in real cases are depicted in detail. Collectively, these characteristics are beneficial in aiding allosteric drug design and allosteric mechanism research.
变构作用被认为是调节生物大分子功能的最直接和有效的方法之一。由于变构调节剂具有高选择性和低毒性等独特优势，变构作用在药物发现领域越来越受到关注。由于变构研究的技术突破，人们对变构蛋白及其变构位点和调节剂等变构实体的特性有了很大的了解。这些特征在变构概念的演变和变构相互作用的预测中都起着关键作用。在本章中，我们强调了变构蛋白、变构位点和变构调节剂的基本特征。重要的是，详细描述了这些原理在实际案例中的应用。总之，这些特征有助于变构药物设计和变构机制研究。
