State Key Laboratory of Microbial Metabolism, Department of Bioinformatics and Biostatistics, National Experimental Teaching Center for Life Sciences and Biotechnology, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China.
Department of Biochemistry, Abdul Wali Khan University Mardan, Mardan, Pakistan.
Adv Exp Med Biol. 2019;1163:335-357. doi: 10.1007/978-981-13-8719-7_14.
The allosteric property of globular proteins is applauded as their intrinsic ability to regulate distant sites, and this property further plays a critical role in a wide variety of cellular regulatory mechanisms. Recent advancements and studies have revealed the manifestation of allostery in intrinsically disordered proteins or regions as allosteric sites present within or mediated by IDP/IDRs facilitates the signaling interactions for various biological mechanisms which would otherwise be impossible for globular proteins to regulate. This thematic review has highlighted the biological outcomes that can be achieved by the mechanism of allosteric regulation of intrinsically disordered proteins or regions. The similar mechanism has been implemented on Adenovirus 5 early region 1A and tumor apoptosis protein p53 in correspondence with other partners in binary and ternary complexes, which are the subject of the current review. Both these proteins regulate once they bind to their partners, consequently, forming either a binary or a ternary complex. Allosteric regulation by IDPs is currently a subject undergoing intense study, and the ongoing research work will ensure a better understanding of precision and efficiency of cellular regulation by them. Allosteric regulation mechanism can also be researched by intrinsically disordered protein-specific force field.
球蛋白的变构特性被称赞为其调节远距离部位的固有能力，这种特性在多种细胞调节机制中起着关键作用。最近的进展和研究表明，在无规则卷曲蛋白质或区域中存在变构位点，这些变构位点存在于无规则卷曲蛋白质或区域内或由其介导，这为各种生物学机制的信号转导相互作用提供了便利，否则球蛋白无法调节这些机制。本主题综述强调了通过变构调节无规则卷曲蛋白质或区域的机制可以实现的生物学结果。类似的机制已在腺病毒 5 早期区域 1A 和肿瘤凋亡蛋白 p53 中与二元和三元复合物中的其他伙伴对应实施，这是当前综述的主题。这两种蛋白质一旦与它们的伙伴结合，就会进行调节，从而形成二元或三元复合物。无规则卷曲蛋白质的变构调节目前是一个正在进行深入研究的课题，正在进行的研究工作将确保更好地理解它们对细胞调节的精确性和效率。无规则卷曲蛋白质的变构调节机制也可以通过无规则卷曲蛋白质的特定力场进行研究。
