拓展范式：固有无序蛋白质与变构调节。
Expanding the Paradigm: Intrinsically Disordered Proteins and Allosteric Regulation.
机构信息
Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
Department of Integrative Structural and Computational Biology and Skaggs Institute of Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
J Mol Biol. 2018 Aug 3;430(16):2309-2320. doi: 10.1016/j.jmb.2018.04.003. Epub 2018 Apr 7.
Allosteric regulatory processes are implicated at all levels of biological function. Recent advances in our understanding of the diverse and functionally significant class of intrinsically disordered proteins have identified a multitude of ways in which disordered proteins function within the confines of the allosteric paradigm. Allostery within or mediated by intrinsically disordered proteins ensures robust and efficient signal integration through mechanisms that would be extremely unfavorable or even impossible for globular protein interaction partners. Here, we highlight recent examples that indicate the breadth of biological outcomes that can be achieved through allosteric regulation by intrinsically disordered proteins. Ongoing and future work in this rapidly evolving area of research will expand our appreciation of the central role of intrinsically disordered proteins in ensuring the fidelity and efficiency of cellular regulation.
变构调节过程涉及生物功能的各个层面。我们对结构无序蛋白质这一具有多样功能且意义重大的蛋白质家族的理解不断深入，发现了许多结构无序蛋白质在变构范例限制下发挥功能的方式。结构无序蛋白质内部或通过结构无序蛋白质介导的变构作用确保了通过极其不利甚至不可能的球蛋白相互作用伙伴的信号整合的强大和高效。在这里，我们强调了最近的一些例子，这些例子表明可以通过结构无序蛋白质的变构调节来实现广泛的生物学结果。在这个快速发展的研究领域中正在进行和未来的工作将扩大我们对结构无序蛋白质在确保细胞调节的保真度和效率的核心作用的认识。
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