Rismondo V, Ubels J L, Osgood T B
Department of Physiology, Medical College of Wisconsin, Milwaukee 53226.
J Am Acad Dermatol. 1988 Aug;19(2 Pt 1):280-5. doi: 10.1016/s0190-9622(88)70172-3.
Adverse ocular reactions including dry eye symptoms and blepharoconjunctivitis are common side effects of treatment with isotretinoin (13-cis-retinoic acid). However, there is little agreement in the literature on the effect of this drug on the tears. Because we have previously shown that the lacrimal gland secretes isotretinoin, we conducted a study of the effect of isotretinoin on lacrimal gland function. Rabbits were treated with isotretinoin for 5 months. Throughout the study tear secretion was monitored by the Schirmer test. At the end of the study lacrimal gland function was assessed by measurement of fluid and protein secretion rates and secretion of retinol in response to a pilocarpine stimulus. Lacrimal gland function was not affected by isotretinoin as compared with a group of age-matched control rabbits; however, Schirmer test scores were significantly increased in the treated animals as compared with control values. We conclude that isotretinoin is not toxic to the lacrimal gland of rabbits. This suggests that ocular irritation in patients treated with isotretinoin is not caused by decreased tear secretion during therapy.
包括干眼症状和睑结膜炎在内的眼部不良反应是异维A酸（13-顺式维甲酸）治疗的常见副作用。然而，关于这种药物对泪液的影响，文献中几乎没有一致的观点。因为我们之前已经表明泪腺会分泌异维A酸，所以我们进行了一项关于异维A酸对泪腺功能影响的研究。用异维A酸治疗兔子5个月。在整个研究过程中，通过Schirmer试验监测泪液分泌。在研究结束时，通过测量毛果芸香碱刺激后的液体和蛋白质分泌率以及视黄醇分泌来评估泪腺功能。与一组年龄匹配的对照兔子相比，异维A酸对泪腺功能没有影响；然而，与对照值相比，治疗组动物的Schirmer试验评分显著增加。我们得出结论，异维A酸对兔子的泪腺没有毒性。这表明接受异维A酸治疗的患者眼部刺激不是由治疗期间泪液分泌减少引起的。
