Rismondo V, Ubels J L
Arch Ophthalmol. 1987 Mar;105(3):416-20. doi: 10.1001/archopht.1987.01060030136044.
Isotretinoin (13-cis-retinoic acid) is used in the treatment of severe cystic acne. Adverse ocular reactions, including blepharoconjunctivitis and dry eye symptoms, are frequent side effects of this drug. Our previous observation that retinol is present in tears and lacrimal gland fluid suggests that isotretinoin may also be secreted by the lacrimal gland. Rabbits were treated with isotretinoin, and lacrimal gland fluid was collected from the cannulated lacrimal gland duct. Tears were collected from patients who were being treated with isotretinoin. Lacrimal gland fluid and tears were analyzed by reverse-phase high-pressure liquid chromatography and a peak eluted from each sample, which was identified as isotretinoin. We conclude that the lacrimal gland is able to secrete isotretinoin in addition to retinol and that, in animals and patients treated systemically with isotretinoin, the ocular surface is exposed to the drug via the tear film.
异维A酸（13 - 顺式维甲酸）用于治疗重度囊肿性痤疮。包括睑结膜炎和干眼症状在内的眼部不良反应是该药物常见的副作用。我们之前观察到泪液和泪腺液中存在视黄醇，这表明异维A酸也可能由泪腺分泌。给兔子使用异维A酸进行治疗，并从插管的泪腺导管收集泪腺液。从正在接受异维A酸治疗的患者中收集泪液。通过反相高压液相色谱法分析泪腺液和泪液，每个样品都洗脱出色谱峰，该峰被鉴定为异维A酸。我们得出结论，泪腺除了能分泌视黄醇外，还能够分泌异维A酸，并且在全身使用异维A酸治疗的动物和患者中，眼表会通过泪膜接触到该药物。
