van der Walt K, Wootton O, Rokicki J, Vaskinn A, Jonker D, Campbell M, Susser E, Haukvik U K, Gur R C, Stein D J, Friestad C
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa.
Centre for Research and Education in Forensic Psychiatry, Oslo University Hospital, Oslo, Norway.
Schizophr Res Cogn. 2025 Aug 19;42:100382. doi: 10.1016/j.scog.2025.100382. eCollection 2025 Dec.
People living with schizophrenia (PLS) are at increased risk of being both victims and perpetrators of violence. Recent research suggests that social cognitive impairments may contribute to heightened aggression in schizophrenia. Childhood trauma, a well-established risk factor for both schizophrenia and aggression, is also linked to more severe cognitive deficits in PLS. Few studies have explored the relationships between childhood trauma, social cognition, and aggression in large sample sizes, particularly in low- and middle-income settings, where varying socioeconomic factors and exposure to violence may influence these associations. In this study, a subsample of participants (PLS = 585; controls = 882) from the study completed The Childhood Trauma Questionnaire (CTQ), Penn Emotion Identification Test (ER), Life History of Aggression Questionnaire (LHA), and Structured Diagnostic Interview for DSM-IV Axis I Disorders. Group differences in CTQ, ER, LHA, and selected demographic and clinical factors were assessed using -tests and chi-square tests. Multivariable linear regressions were employed to test for associations among CTQ, ER, and LHA. We found that PLS had significantly higher childhood trauma and lifetime aggression scores and poorer emotion recognition performance than controls. Higher childhood trauma was associated with higher lifetime aggression and worse emotion recognition performance. However, emotion recognition performance was not associated with lifetime aggression. In this setting, childhood trauma predicts lifetime aggression and poorer emotion recognition, but there is no evidence that emotion recognition ability is related to aggression.
精神分裂症患者（PLS）成为暴力受害者和施暴者的风险都有所增加。最近的研究表明，社会认知障碍可能导致精神分裂症患者的攻击性增强。童年创伤是精神分裂症和攻击性的一个既定风险因素，也与PLS患者更严重的认知缺陷有关。很少有研究在大样本中探讨童年创伤、社会认知和攻击性之间的关系，特别是在低收入和中等收入环境中，不同的社会经济因素和暴力暴露可能会影响这些关联。在本研究中，来自该研究的一部分参与者（PLS = 585；对照组 = 882）完成了儿童创伤问卷（CTQ）、宾夕法尼亚情绪识别测试（ER）、攻击行为生活史问卷（LHA）以及DSM-IV轴I障碍结构化诊断访谈。使用t检验和卡方检验评估CTQ、ER、LHA以及选定的人口统计学和临床因素的组间差异。采用多变量线性回归来检验CTQ、ER和LHA之间的关联。我们发现，与对照组相比，PLS患者的童年创伤和终生攻击得分显著更高，情绪识别表现更差。童年创伤程度越高，终生攻击性越强，情绪识别表现越差。然而，情绪识别表现与终生攻击性无关。在这种情况下，童年创伤可预测终生攻击性和较差的情绪识别能力，但没有证据表明情绪识别能力与攻击性有关。
