Mackie P H, Crockson R A, Stuart J
J Clin Pathol. 1979 Dec;32(12):1253-6. doi: 10.1136/jcp.32.12.1253.
C-reactive protein, measured in serum from 38 patients with leukaemia, was elevated to at least 100 mg/l at the beginning of 32 of 34 episodes of infection, and subsequently rose above 100 mg/l in all 34. Uninfected patients, whether in leukaemic remission or relapse and whether pyrexial or not, always had levels below 100 mg/l, with four exceptions out of 290 measurements. Estimation of two other acute-phase proteins, alpha 1-antitrypsin and orosomucoid, was not of additional diagnostic value. Serial measurement of C-reactive protein may be important for the early detection of infection in the leukaemic patient with neutropenia.
对38例白血病患者血清中的C反应蛋白进行检测，在34次感染发作中的32次发作开始时，该蛋白升高至至少100mg/L，随后在所有34次发作中均升至100mg/L以上。未感染的患者，无论处于白血病缓解期还是复发期，无论是否发热，C反应蛋白水平均始终低于100mg/L，在290次测量中有4次例外。另外两种急性期蛋白α1抗胰蛋白酶和类粘蛋白的检测没有额外的诊断价值。对中性粒细胞减少的白血病患者进行C反应蛋白的连续检测可能对早期发现感染很重要。
