Starke I D, de Beer F C, Donnelly J P, Catovsky D, Goldman J M, Galton D A, Pepys M B
Eur J Cancer Clin Oncol. 1984 Mar;20(3):319-25. doi: 10.1016/0277-5379(84)90076-2.
C-reactive protein (CRP) was measured serially in 29 patients with acute leukaemia. Sixty-four febrile episodes (greater than or equal to 38 degrees C) occurred during 37 periods of neutropenia (less than 0.5 X 10(9)/l). In all of 41 microbiologically or clinically documented infections the maximum CRP level exceeded 30 mg/l, and in 25 it was greater than 100 mg/l. In no case in which the CRP level remained below 30 mg/l for 48 hr after the onset of fever was any clinical or microbiological evidence of infection obtained. The CRP level during documented infection began to fall 24-48 hr after appropriate treatment was begun. A CRP level above 30 mg/l in neutropenic patients was associated with early recurrence of fever if systemic antibiotics were discontinued. Graft-vs-host disease, without infection, did not result in high levels of CRP.
对29例急性白血病患者连续检测C反应蛋白（CRP）。在37个中性粒细胞减少期（低于0.5×10⁹/L）出现了64次发热发作（体温≥38℃）。在所有41例经微生物学或临床证实的感染中，CRP最高水平超过30mg/L，25例大于100mg/L。发热开始后48小时内CRP水平持续低于30mg/L的患者，均未获得感染的临床或微生物学证据。确诊感染开始适当治疗后24 - 48小时，CRP水平开始下降。如果停用全身抗生素，中性粒细胞减少患者CRP水平高于30mg/L与发热早期复发有关。无感染的移植物抗宿主病不会导致CRP水平升高。
