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C reactive protein rapid assay techniques for monitoring resolution of infection in immunosuppressed patients.

作者信息

Harris R I, Stone P C, Hudson A G, Stuart J

出版信息

J Clin Pathol. 1984 Jul;37(7):821-5. doi: 10.1136/jcp.37.7.821.

Abstract

Three rapid assay techniques (latex agglutination, laser nephelometry, and EMIT enzyme immunoassay) have been evaluated for serial monitoring of the serum C reactive protein (CRP) concentration in immunosuppressed patients with fever. Radial immunodiffusion assay was used as a reference method. Latex agglutination reliably distinguished between normal and raised serum CRP concentrations. Enzyme immunoassay also provided a result within minutes, showed particularly close correlation (r = 0.967) with the reference method, and was free from interference by lipaemic or icteric sera. In 27% of 55 episodes of fever studied serially in immunosuppressed patients, the enzyme immunoassay provided clinically useful information by indicating incomplete resolution of infection despite resolution of fever.

摘要

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