Harris R I, Stone P C, Hudson A G, Stuart J
J Clin Pathol. 1984 Jul;37(7):821-5. doi: 10.1136/jcp.37.7.821.
Three rapid assay techniques (latex agglutination, laser nephelometry, and EMIT enzyme immunoassay) have been evaluated for serial monitoring of the serum C reactive protein (CRP) concentration in immunosuppressed patients with fever. Radial immunodiffusion assay was used as a reference method. Latex agglutination reliably distinguished between normal and raised serum CRP concentrations. Enzyme immunoassay also provided a result within minutes, showed particularly close correlation (r = 0.967) with the reference method, and was free from interference by lipaemic or icteric sera. In 27% of 55 episodes of fever studied serially in immunosuppressed patients, the enzyme immunoassay provided clinically useful information by indicating incomplete resolution of infection despite resolution of fever.
已对三种快速检测技术（乳胶凝集法、激光散射比浊法和酶放大免疫测定技术）进行评估，用于连续监测发热的免疫抑制患者血清C反应蛋白（CRP）浓度。采用单向免疫扩散试验作为参考方法。乳胶凝集法能可靠地区分正常和升高的血清CRP浓度。酶免疫测定法也能在数分钟内得出结果，与参考方法显示出特别密切的相关性（r = 0.967），且不受脂血或黄疸血清的干扰。在对55例免疫抑制患者发热发作进行连续研究的过程中，27%的病例中酶免疫测定法通过表明尽管发热已消退但感染并未完全消除，提供了临床有用信息。
