Department of Family Medicine, Faculty of Medicine, Cairo University, Egypt.
Department of Dermatology, Faculty of Medicine, Cairo University, Egypt.
J Trace Elem Med Biol. 2020 May;59:126422. doi: 10.1016/j.jtemb.2019.126422. Epub 2019 Oct 30.
Pityriasis Alba (PA) is a common skin disorder affecting the children and it has multiple risk factors.
To assess the serum levels of trace elements (copper, zinc, and magnesium) and hemoglobin (Hb) level in patients with PA.
This is a case control study; 110 participants (55 cases and 55 controls) were recruited from pediatric dermatology and family medicine clinics, Cairo university hospitals. Patients were allocated into two groups, PA group (randomly selected male and female children age group (6-16) with PA lesions) and a matched control group. Full history was taken including sociodemographic data, present history of the lesions. Full general and dermatological examination was done. Blood samples were taken to asses iron and trace elements levels. The gained measures were analyzed by (SPSS) program version 22.
This study showed that Hb levels, serum ferritin, copper, zinc and magnesium were significantly lower in PA group. There was statistically significant difference between both cases and controls regarding trace elements (copper, zinc, and magnesium) with (p value was 0.000, 0.000 and 0.003) respectively. Zinc deficiency increased the risk by more than 15 folds. Also, there was statistically significant difference between both groups regarding Hb levels and serum ferritin (p value was 0.000). The reduced Hb level increases the risk of PA by more than nine folds (OR 9.6) CONCLUSION: PA is associated with reduced levels of Hb, serum zinc, ferritin, copper and magnesium; sun exposure, skin phototype were found to be important risk factors for PA.
白色糠疹（PA）是一种常见的儿童皮肤病，有多种危险因素。
评估白色糠疹患者血清微量元素（铜、锌、镁）和血红蛋白（Hb）水平。
这是一项病例对照研究；从开罗大学医院的儿科皮肤科和家庭医学诊所招募了 110 名参与者（55 例病例和 55 名对照）。将患者分为两组，PA 组（随机选择年龄在 6-16 岁之间的男性和女性儿童有 PA 病变）和匹配的对照组。采集完整的病史，包括社会人口统计学数据、目前的病变史。进行全面的体格检查和皮肤科检查。采集血液样本以评估铁和微量元素水平。所得测量值由（SPSS）程序版本 22 进行分析。
本研究表明，PA 组的 Hb 水平、血清铁蛋白、铜、锌和镁均显著降低。病例组和对照组在微量元素（铜、锌和镁）方面存在统计学差异（p 值分别为 0.000、0.000 和 0.003）。锌缺乏使风险增加超过 15 倍。此外，两组在 Hb 水平和血清铁蛋白方面也存在统计学差异（p 值分别为 0.000）。Hb 水平降低使 PA 的风险增加超过 9 倍（OR 9.6）。
PA 与 Hb、血清锌、铁蛋白、铜和镁水平降低有关；阳光暴露、皮肤光型被认为是 PA 的重要危险因素。
