Ohlerth Stefanie, Geiser Britta, Flückiger Mark, Geissbühler Urs
Clinic for Diagnostic Imaging, Department of Clinical Services and Diagnostics, University of Zurich, Zurich, Switzerland.
Section of Clinical Radiology, Department of Clinical Veterinary Medicine, University of Bern, Bern, Switzerland.
Front Vet Sci. 2019 Oct 24;6:378. doi: 10.3389/fvets.2019.00378. eCollection 2019.
Canine hip dysplasia (CHD) is a genetic disease, modulated by epigenetic and environmental factors. To decrease the prevalence of CHD, the hip joints of many pure breed dogs are radiographed to identify dysplastic dogs not qualified for breeding. It has been shown that both, prevalence and severity of CHD may be reduced on the basis of phenotypic i.e., radiographic selection of breeding animals. The method has been used in many countries for over 50 years. In the present study, severity and prevalence of CHD in five common large breeds in Switzerland were evaluated since 1995. Both, prevalence and severity of CHD dropped in each breed between the periods 1995-1999 and 2010-2016. The prevalence decreased in Golden Retrievers from 25 to 9% and in Labrador Retrievers from 16 to 3%, respectively. In the Flat-Coated Retriever, prevalence in general was low, decreasing from 6 to 3%. In the Bernese mountain dog and the German shepherd dog, a decrease from 21 to 12% and from 46 to 18%, respectively, was observed. However, the rather low overall rate of radiographed dogs (Retrievers: 11 to 18%, Bernese Mountain dogs: 23% and German Shepherd dogs: 31%) does not allow to draw reliable conclusions regarding the true prevalence of CHD for the entire population of these breeds in Switzerland.
犬髋关节发育不良(CHD)是一种受表观遗传和环境因素影响的遗传疾病。为了降低CHD的患病率,许多纯种犬的髋关节都进行了X光检查,以识别不符合繁殖标准的发育不良犬只。研究表明,基于表型(即通过X光对繁殖动物进行筛选),CHD的患病率和严重程度都可能降低。该方法在许多国家已使用了50多年。在本研究中,自1995年以来对瑞士五个常见大型犬种的CHD严重程度和患病率进行了评估。在1995 - 1999年和2010 - 2016年期间,每个犬种的CHD患病率和严重程度均有所下降。金毛寻回犬的患病率从25%降至9%,拉布拉多寻回犬的患病率从16%降至3%。平毛寻回犬的患病率总体较低,从6%降至3%。伯恩山犬和德国牧羊犬的患病率分别从21%降至12%和从46%降至18%。然而,接受X光检查的犬只总体比例相对较低(寻回犬:$11%$至$18%$,伯恩山犬:$23%$,德国牧羊犬:$31%$),因此无法就瑞士这些犬种的整个种群中CHD的真实患病率得出可靠结论。