College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education , Shandong Normal University , Jinan 250014 , P. R. China.
Inorg Chem. 2018 Mar 19;57(6):3169-3176. doi: 10.1021/acs.inorgchem.7b03204. Epub 2018 Feb 28.
Herein, we report an iodine-attached Zn(II)-porphyrinic dicarboxylic building block (ZnDTPP-I-2H, 1) that can be introduced into UiO-66 NMOF via one-pot synthetic approach to generate a new ZnDTPP-I doped UiO-66 type nano metal-organic framework (NMOF) of ZnDTPP-I⊂UiO-66 (2). Compared to its homologous iodine-free NMOF of ZnDTPP⊂UiO-66 (4), ZnDTPP-I⊂UiO-66 (2) with heavy iodine atoms is a more effective nanosized photosensitizer for singlet oxygen generation under physiological conditions. As expected, 2 displayed a high photodynamic therapy efficacy for treatment of liver cancer cells in vitro.
在此，我们报告了一个碘连接的 Zn(II)-卟啉二羧酸建筑块（ZnDTPP-I-2H，1），它可以通过一锅合成方法引入 UiO-66 NMOF 中，生成一种新的 ZnDTPP-I 掺杂的 UiO-66 型纳米金属-有机骨架（NMOF）的 ZnDTPP-I⊂UiO-66（2）。与同族的无碘 NMOF 的 ZnDTPP⊂UiO-66（4）相比，具有重碘原子的 ZnDTPP-I⊂UiO-66（2）是一种在生理条件下生成单线态氧的更有效的纳米光敏剂。正如预期的那样，2 在体外治疗肝癌细胞方面表现出了很高的光动力治疗效果。
