College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education , Shandong Normal University , Jinan 250014 , People's Republic of China.
Shandong Analysis and Test Center , Qilu University of Technology (Shandong Academy of Sciences) , Jinan , Shandong 250014 , People's Republic of China.
Inorg Chem. 2018 May 7;57(9):5420-5428. doi: 10.1021/acs.inorgchem.8b00384. Epub 2018 Apr 17.
Nanocrystallization of organic molecular photosensitizers (PSs) by means of NMOF platforms has been demonstrated to be a promising approach to build up highly efficient PDT therapeutics. We report herein a new UiO-66 type of NMOF-based PS (UiO-66-TPP-SH), which is generated from UiO-66 NMOF and S-ethylthiol ester monosubstituted metal free porphyrin (TPP-SH) via a facile postsynthetic approach under mild conditions. The obtained NMOF (size less than 150 nm) with surface-decorated porphyrinic PS can not only retain MOF crystallinity, structural feature, and size, but also exhibit highly efficient singlet oxygen generation. Compared to the interior-located porphyrinic NMOF, UiO-66-TPP-SH shows significantly higher photodynamic activity and more efficient PDT tumor treatment.
通过 NMOF 平台对有机分子光敏剂 (PSs) 进行纳米结晶已被证明是构建高效 PDT 治疗方法的一种很有前途的方法。我们在此报告了一种新型基于 UiO-66 类型的 NMOF 的 PS（UiO-66-TPP-SH），它是通过在温和条件下通过简便的后合成方法从 UiO-66 NMOF 和 S-乙基硫醇酯单取代无金属卟啉 (TPP-SH) 生成的。所得的具有表面修饰卟啉 PS 的 NMOF（尺寸小于 150nm）不仅保留了 MOF 的结晶度、结构特征和尺寸，而且还表现出高效的单线态氧生成。与位于内部的卟啉 NMOF 相比，UiO-66-TPP-SH 表现出更高的光动力活性和更有效的 PDT 肿瘤治疗效果。
