School of Forensic Medicine, China Medical University, Shenyang, Liaoning Province, P. R. China.
J Int Med Res. 2020 Jun;48(6):300060520926364. doi: 10.1177/0300060520926364.
A growing number of studies have reported that genes involved in the repair of DNA double-strand breaks might be cancer-susceptibility genes. The x-ray cross-complementing group 4 gene () encodes a protein that functions in the repair of DNA double-strand breaks, and this meta-analysis aimed to investigate the relationship between the rs1805377 polymorphism and cancer occurrence.
We retrieved case-control studies that met the inclusion criteria from PubMed, Web of Science, Embase, and China National Knowledge Infrastructure databases. Associations between rs1805377 and cancer risk were evaluated by odds ratios (ORs) using a random effects model and 95% confidence intervals (CIs) as well as sensitivity and subgroup analyses.
After inclusion criteria were met, the meta-analysis involved 24 studies that included 9,633 cancer patients and 10,544 healthy controls. No significant association was found between rs1805377 and the risk of cancer (pooled OR = 1.107; 95% CI = 0.955-1.284) in the dominant genetic model. Similarly, no significant association was observed in the subgroup analysis.
Through this meta-analysis, we found no association between the rs1805377 polymorphism and cancer occurrence. This may provide useful information for relevant future studies into the etiology of cancer.
越来越多的研究报告称，参与 DNA 双链断裂修复的基因可能是癌症易感性基因。X 射线修复交叉互补基因 4 （）编码一种在 DNA 双链断裂修复中起作用的蛋白质，本荟萃分析旨在研究 rs1805377 多态性与癌症发生之间的关系。
我们从 PubMed、Web of Science、Embase 和中国国家知识基础设施数据库中检索符合纳入标准的病例对照研究。使用随机效应模型和 95%置信区间（CI）以及敏感性和亚组分析评估 rs1805377 与癌症风险之间的关联，使用比值比（OR）表示。
符合纳入标准后，荟萃分析纳入了 24 项研究，共纳入 9633 例癌症患者和 10544 例健康对照。在显性遗传模型中，rs1805377 与癌症风险之间无显著相关性（合并 OR=1.107；95%CI=0.955-1.284）。同样，在亚组分析中也未观察到显著相关性。
通过本荟萃分析，我们未发现 rs1805377 多态性与癌症发生之间存在关联。这可能为癌症病因学的相关未来研究提供有用信息。
