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[轻度认知障碍患者和痴呆患者的诊断程序]

[Diagnostic procedures in patients with mild cognitive impairment and in patients with dementia].

作者信息

Schulz M, von Stillfried D, Bohlken J

机构信息

Zentralinstitut für die kassenärztliche Versorgung in Deutschland (Zi), Salzufer 8, 10587, Berlin, Deutschland.

Praxis für Neurologie und Psychiatrie - Berlin, Berlin, Deutschland.

出版信息

Nervenarzt. 2020 Feb;91(2):141-147. doi: 10.1007/s00115-019-00829-4.

Abstract

BACKGROUND

To manage the growing numbers of people with dementia (PwD) preventive strategies are becoming more important. Therefore, the diagnostics of patients with mild cognitive impairment (PwMCI) are gaining in importance. Little is known about the current use of diagnostics tests among PwMCI in routine healthcare. The aim of the study was to examine the prevalence of diagnostic methods in newly diagnosed PwMCI over time in comparison to PwD.

METHODS

The study was based on the complete nationwide patient claims data of the panel doctor services according to §295 of the German social code book V (SGB V). The incidences of PwMCI and PwD in 2011 and 2016 were identified and the use of neuropsychiatric testing, neuroimaging with computed tomography (CT) and magnetic resonance imaging (MRI), laboratory and cerebrospinal fluid (CSF) examinations was ascertained.

RESULTS

In 2016 the prevalence of neuroimaging as well as of laboratory examinations was higher in PwMCI compared to PwD (29% vs. 21% and 92% vs. 88%, respectively). There were only small differences in neuropsychiatric testing (70% vs. 72%). The prevalence of CSF examinations was very low in both groups (less than 1%). Between 2011 and 2016 the prevalence of neuroimaging decreased from 36% to 29% among PwMCI, while it remained constant at around 22% for PwD. The rates of neuropsychiatric testing increased over time in both PwMCI (from 49% to 70%) and PwD (from 36% to 72%). The prevalence of laboratory examinations remained unchanged.

CONCLUSION

The use of specific diagnostic methods was higher in PwMCI than in PwD. Referring to the recommendations of practice guidelines, the increase in neuropsychiatric testing is regarded as a pleasing development, whereas the decrease in neuroimaging rates and the very low prevalence of CSF examinations require improvement.

摘要

背景

为应对痴呆患者人数的不断增加,预防策略变得愈发重要。因此,轻度认知障碍患者的诊断变得越发重要。对于日常医疗中轻度认知障碍患者目前诊断测试的使用情况,人们了解甚少。本研究的目的是,与痴呆患者相比,研究新诊断的轻度认知障碍患者中诊断方法的流行情况随时间的变化。

方法

本研究基于德国社会法典第五编(SGB V)第295条规定的全国范围内全科医生服务的完整患者索赔数据。确定了2011年和2016年轻度认知障碍患者和痴呆患者的发病率,并确定了神经精神测试、计算机断层扫描(CT)和磁共振成像(MRI)神经影像学检查、实验室检查和脑脊液(CSF)检查的使用情况。

结果

2016年,轻度认知障碍患者的神经影像学检查和实验室检查的流行率高于痴呆患者(分别为29%对21%和92%对88%)。神经精神测试的差异很小(70%对72%)。两组脑脊液检查的流行率都非常低(低于1%)。2011年至2016年期间,轻度认知障碍患者中神经影像学检查的流行率从36%降至29%,而痴呆患者则保持在22%左右不变。神经精神测试的比例在轻度认知障碍患者(从49%升至70%)和痴呆患者(从36%升至72%)中均随时间增加。实验室检查的流行率保持不变。

结论

轻度认知障碍患者中特定诊断方法的使用高于痴呆患者。参照实践指南的建议,神经精神测试的增加被视为一个令人满意的进展,而神经影像学检查比例的下降和脑脊液检查的极低流行率需要改进。

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