Agren H, Niklasson F
Department of Psychiatry (North), University Hospital Uppsala, Sweden.
J Neural Transm. 1988;74(1):55-9. doi: 10.1007/BF01243575.
In an attempt to chemically estimate cerebral energy metabolism, creatine and creatinine was measured in cerebrospinal fluid and plasma of up to 135 patients with RDC diagnoses of major depressive disorders. A strong positive age effect and a significant subdiagnostic difference were detected for both substances in CSF, but not in plasma. Primary unipolar patients had higher concentrations than either secondary unipolar or bipolar patients. Further, the two CSF measures correlated highly significantly and positively with the CSF monoamine metabolites HVA and 5-HIAA and the purine metabolites hypoxanthine and xanthine. Results indicate alterations in energy metabolism to be involved in affective disorders as well as in the regulation of monoamine and purine turnover.
为了从化学角度评估大脑能量代谢，我们对多达135例经研究诊断标准委员会（RDC）确诊为重度抑郁症的患者的脑脊液和血浆中的肌酸和肌酐进行了测量。在脑脊液中，这两种物质均检测到显著的年龄正效应和亚诊断差异，但在血浆中未检测到。原发性单相抑郁症患者的浓度高于继发性单相抑郁症患者或双相情感障碍患者。此外，脑脊液中的这两项测量结果与脑脊液单胺代谢产物高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）以及嘌呤代谢产物次黄嘌呤和黄嘌呤高度显著正相关。结果表明，能量代谢改变与情感障碍以及单胺和嘌呤周转的调节有关。
