International Institute of Tropical Agriculture (IITA), Food and Nutrition Sciences Laboratory, Chelstone, Zambia.
Plant Pathology Unit, IITA, Chelstone, Zambia.
Int J Food Sci Nutr. 2020 Aug;71(5):593-603. doi: 10.1080/09637486.2019.1689547. Epub 2019 Nov 12.
In Zambia, mothers/caregivers feed their children cereal-based complementary foods that are prone to aflatoxin contamination. This study evaluated the relationship between exposure to aflatoxins and the nutritional status of young children. It covered 400 mothers with children aged 6-24 months. Their nutritional status assessed by measuring weight and height using standard procedures. Serum samples analysed for aflatoxin B1-lysine (AFB1-lys), a reliable biomarker of aflatoxin exposure. Child sickness and age, exposure to aflatoxin in foods, and albumin-normalised AFB1-lys level were found to be significantly ( <05) associated with child stunting except for child age that was not significant at =05. Children with an increase in the blood serum aflatoxin B1 lysine adduct are more likely to be stunted. These results have shown that dietary exposure to aflatoxin could lead to an increase in serum aflatoxin concentrations, both of which are associated with stunting.
在赞比亚，母亲/照顾者给孩子喂食以谷物为基础的补充食品，这些食品容易受到黄曲霉毒素的污染。本研究评估了接触黄曲霉毒素与幼儿营养状况之间的关系。研究涵盖了 400 名年龄在 6-24 个月的儿童的母亲。他们的营养状况通过使用标准程序测量体重和身高来评估。对血清样本进行了黄曲霉毒素 B1-赖氨酸（AFB1-lys）分析，这是黄曲霉毒素暴露的可靠生物标志物。除了儿童年龄在 0.05 水平上不显著外，儿童疾病和年龄、食物中黄曲霉毒素的暴露以及白蛋白标准化的 AFB1-lys 水平与儿童发育迟缓显著相关。血液中黄曲霉毒素 B1 赖氨酸加合物增加的儿童更有可能发育迟缓。这些结果表明，膳食接触黄曲霉毒素可能导致血清黄曲霉毒素浓度增加，这两者都与发育迟缓有关。
