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唾液成分分析：生长发育迟缓的褐家鼠体内的甲状旁腺激素相关蛋白、总蛋白和分泌型免疫球蛋白A（sIgA）

Analysis of Saliva Composition: Parathyroid Hormone-Related Protein, Total Protein, and Secretory Immunoglobulin A (sIgA) in Rattus norvegicus with Stunted Growth.

作者信息

Tedjosasongko Udijanto, Nelwan Sindy Cornelia, Wahluyo Soegeng, Puteri Mega Moeharyono, Dewi Ardianti Maartrina, Rahayu Retno Pudji, Ardiwirastuti Ilvana, Ayuningtyas Puspita, Pramudita Regina Ayu, Marwah Aisyah

机构信息

Department of Pediatric Dentistry, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

Department of Oral Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.

出版信息

Eur J Dent. 2023 Jul;17(3):765-770. doi: 10.1055/s-0042-1755558. Epub 2022 Oct 11.

DOI:10.1055/s-0042-1755558
PMID:36220123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10569847/
Abstract

OBJECTIVE

This study aimed to determine total protein, secretory immunoglobulin A (sIgA) and parathyroid hormone-related protein (PTHrP) levels in the saliva of rats with stunted growth.

MATERIALS AND METHODS

Experimental laboratory research with a pre-and posttest control group design was conducted. Seventeen albino rats () were divided into the control group (eight rats) and the treatment group (nine rats). Rats in the treatment group were exposed to aflatoxin B1 5µg/kg orally for 5 weeks. Anthropometry data (body length, body weight) and saliva of were collected. The levels of PTHrP and sIgA in the saliva were measured using an enzyme-linked immunosorbent assay kit for rats and the Bradford test for total protein and analyzed using SPSS 25.0.

RESULTS

Aflatoxin caused stunted growth in rats in the treatment group. There was a significant difference in body length, salivary flow, PTHrP, sIgA, and total protein in the treatment group compared with the control group. The average rat's body length change in the control group was 6.4 ± 1.1mm/5 weeks, while in the treatment group, the change was 3.7 ± 0.9 mm /5 weeks. There was no significant weight gain in the treatment group compared with the normal group. The average values of PTHrP, sIgA, and total protein in the control group were x̄0.9, x̄18, and x̄0.7 m./L, respectively, while in the treatment group, they measured x̄0.4, x̄10.7, and x̄0.5 mg/L, respectively.

CONCLUSION

This study showed that salivary flow, PTHrP, sIgA, and total protein levels in the saliva were significantly lower in stunted rats compared with normal rats.

摘要

目的

本研究旨在测定生长发育迟缓大鼠唾液中的总蛋白、分泌型免疫球蛋白A（sIgA）和甲状旁腺激素相关蛋白（PTHrP）水平。

材料与方法

采用实验性实验室研究，设计了前后测对照组。将17只白化大鼠分为对照组（8只大鼠）和治疗组（9只大鼠）。治疗组大鼠口服5μg/kg黄曲霉毒素B1，持续5周。收集大鼠的人体测量数据（体长、体重）和唾液。使用大鼠酶联免疫吸附测定试剂盒测量唾液中PTHrP和sIgA的水平，采用Bradford法测量总蛋白，并使用SPSS 25.0进行分析。

结果

黄曲霉毒素导致治疗组大鼠生长发育迟缓。与对照组相比，治疗组大鼠的体长、唾液流量、PTHrP、sIgA和总蛋白存在显著差异。对照组大鼠的平均体长变化为6.4±1.1mm/5周，而治疗组为3.7±0.9mm/5周。与正常组相比，治疗组大鼠体重无显著增加。对照组中PTHrP、sIgA和总蛋白的平均值分别为x̄0.9、x̄18和x̄0.7m./L，而治疗组分别为x̄0.4、x̄10.7和x̄0.5mg/L。

结论

本研究表明，与正常大鼠相比，生长发育迟缓大鼠的唾液流量、PTHrP、sIgA和总蛋白水平显著降低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/e2396173eaa1/10-1055-s-0042-1755558-i2252097-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/7221693b53ac/10-1055-s-0042-1755558-i2252097-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/9c5d72747bc3/10-1055-s-0042-1755558-i2252097-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/4302b2a3f831/10-1055-s-0042-1755558-i2252097-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/9b1f7b6f917d/10-1055-s-0042-1755558-i2252097-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/64b10922e121/10-1055-s-0042-1755558-i2252097-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/e2396173eaa1/10-1055-s-0042-1755558-i2252097-6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/7221693b53ac/10-1055-s-0042-1755558-i2252097-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/9c5d72747bc3/10-1055-s-0042-1755558-i2252097-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/4302b2a3f831/10-1055-s-0042-1755558-i2252097-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/9b1f7b6f917d/10-1055-s-0042-1755558-i2252097-4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/64b10922e121/10-1055-s-0042-1755558-i2252097-5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/230f/10569847/e2396173eaa1/10-1055-s-0042-1755558-i2252097-6.jpg

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本文引用的文献

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Rickets in Children: An Update.儿童佝偻病：最新进展
Biomedicines. 2021 Jun 27;9(7):738. doi: 10.3390/biomedicines9070738.
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Vitamin D deficiency serves as a precursor to stunted growth and central adiposity in zebrafish.维生素 D 缺乏会导致斑马鱼生长迟缓和中心性肥胖。
Sci Rep. 2020 Sep 29;10(1):16032. doi: 10.1038/s41598-020-72622-2.
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Prevalence of stunting and obesity in Ecuador: a systematic review.厄瓜多尔发育迟缓与肥胖症的流行情况：一项系统综述。
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Aflatoxins: Producing-Molds, Structure, Health Issues and Incidence in Southeast Asian and Sub-Saharan African Countries.黄曲霉毒素：产毒霉菌、结构、健康问题及在东南亚和撒哈拉以南非洲国家的发生情况。
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Salivary Immunoglobulin A Secretion and Polymeric Ig Receptor Expression in the Submandibular Glands Are Enhanced in Heat-Acclimated Rats.热适应大鼠颌下腺分泌唾液免疫球蛋白 A 和多聚免疫球蛋白受体表达增强。
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The role of salivary sIgA as protection for dental caries activity in Indonesian children.唾液分泌型免疫球蛋白A在印度尼西亚儿童龋齿活动中的保护作用。
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