Department of Pharmacology and Toxicology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
Department of Nutrition, Science and Research Branch, Islamic Azad University, Tehran, Iran.
BMC Pediatr. 2023 Dec 5;23(1):614. doi: 10.1186/s12887-023-04275-9.
Aflatoxins are regarded as the most potent genotoxic and carcinogenic type of mycotoxins. This meta-analysis was performed to investigate a the relation of aflatoxin B1 (AFB1) to growth measurements of infants/children, including wasting, underweight, stunting, as well as weight-for-age (WAZ), height-for-age (HAZ), and weight-for-height (WHZ) z-scores.
Electronic databases of PubMed, Web of Science, and Scopus were searched to identify related publications. Effect sizes for associations were pooled using the random effects analysis. Subgroup analysis by study design, method used to assess AFB1, and adjustment for covariateswas performed to detect possible sources of heterogeneity.
Pooled analysis of available data showed that AFB1 exposure was negatively associated growth z-scores, including WHZ (β = -0.02, 95%CI = -0.07 to 0.03), with WAZ (β = -0.18, 95%CI = -0.33 to -0.02), and HAZ (β = -0.17, 95%CI = -0.30 to -0.03) in infants/children. There was a remarkable heterogeneity among studies on WAZ and HAZ (P ≤ 0.001). In prospective cohort studies, AFB1 exposure was found to be significantly associated with the elevated risk of underweight (OR = 1.20, 95%CI = 1.03 to 1.40) and stunting (OR = 1.21, 95%CI = 1.11 to 1.33).
This meta-analysis highlighted the importance of AFB1 exposure as a potential risk factor for growth impairment in infants/children.
黄曲霉毒素被认为是最具遗传毒性和致癌性的霉菌毒素。本荟萃分析旨在研究黄曲霉毒素 B1（AFB1）与婴儿/儿童生长测量值的关系，包括消瘦、体重不足、发育迟缓，以及体重与年龄（WAZ）、身高与年龄（HAZ）和体重与身高（WHZ）Z 评分。
检索PubMed、Web of Science 和 Scopus 电子数据库，以确定相关出版物。使用随机效应分析汇总关联的效应大小。通过研究设计、评估 AFB1 方法和协变量调整的亚组分析，以发现可能的异质性来源。
对现有数据的汇总分析表明，AFB1 暴露与生长 Z 评分呈负相关，包括 WHZ（β=-0.02，95%CI=-0.07 至 0.03），WAZ（β=-0.18，95%CI=-0.33 至-0.02）和 HAZ（β=-0.17，95%CI=-0.30 至-0.03）。WAZ 和 HAZ 的研究之间存在显著的异质性（P≤0.001）。在前瞻性队列研究中，AFB1 暴露与体重不足（OR=1.20，95%CI=1.03 至 1.40）和发育迟缓（OR=1.21，95%CI=1.11 至 1.33）的风险增加显著相关。
本荟萃分析强调了 AFB1 暴露作为婴儿/儿童生长受损的潜在危险因素的重要性。
