补充肌醇预防妊娠期糖尿病
Inositol Supplementation in the Prevention of Gestational Diabetes Mellitus.
作者信息
Tahir Faryal, Majid Zainab
机构信息
Internal Medicine, Dow University of Health Sciences, Karachi, PAK.
出版信息
Cureus. 2019 Sep 16;11(9):e5671. doi: 10.7759/cureus.5671.
Abstract
Inositol, an emerging novel therapy for the treatment of gestational diabetes mellitus (GDM), is a cyclic polyol that has insulin-like effects and plays an important role in glucose homeostasis. The conventional treatment of GDM with insulin and oral antihyperglycemic drugs usually comes with side effects, paving the way for and shedding spotlight on clinical trials involving inositol. This review analyzed a host of recent trials that involved inositol supplementation for preventing GDM and their positive outcomes in reducing the rate of GDM among obese and overweight pregnant women, as well as women with polycystic ovarian syndrome (PCOS) or a family history of type 2 diabetes mellitus.
摘要
肌醇是一种新兴的治疗妊娠期糖尿病（GDM）的新型疗法，它是一种环状多元醇，具有胰岛素样作用，在葡萄糖稳态中发挥重要作用。GDM的传统治疗方法是使用胰岛素和口服降糖药，这些方法通常会产生副作用，这为涉及肌醇的临床试验铺平了道路，并使其受到关注。这篇综述分析了一系列最近的试验，这些试验涉及补充肌醇以预防GDM，以及它们在降低肥胖和超重孕妇、多囊卵巢综合征（PCOS）患者或2型糖尿病家族史女性的GDM发生率方面的积极成果。
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