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强直性脊柱炎的延迟诊断:一个被错失的机会?

Delayed Diagnosis of Ankylosing Spondylitis: A Missed Opportunity?

作者信息

Patel Pooja, Hussain Hira, Fahey John

机构信息

Rheumatology, Advocate Aurora Health, Brookfield, USA.

Family Medicine, St. George's University School of Medicine, Ft. Lauderdale, USA.

出版信息

Cureus. 2019 Sep 22;11(9):e5723. doi: 10.7759/cureus.5723.

DOI:10.7759/cureus.5723
PMID:31720191
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6823060/
Abstract

Ankylosing spondylitis is an inflammatory condition involving the axial spine, often associated with the human leukocyte antigen (HLA)-B27 genotype and supporting radiographic imaging findings. Patients develop symptomatic low back and/or hip pain beginning in late adolescence or early adulthood. Diagnosis of ankylosing spondylitis is based primarily on clinical presentation and imaging studies. In this article, we are presenting a case of a 40-year-old male patient who presented to the office with chief concerns of chronic mid-thoracic back pain and restricted range of motion of his neck. The imaging study obtained was suggestive of fusion of the sacroiliac joints. This article also highlights the presence of elevated inflammatory markers in the setting of the patients chronic symptomatic complaints which could have guided in early diagnosis.

摘要

强直性脊柱炎是一种累及中轴脊柱的炎症性疾病,常与人类白细胞抗原(HLA)-B27基因型相关,并伴有支持性的影像学检查结果。患者在青春期晚期或成年早期开始出现有症状的下背部和/或臀部疼痛。强直性脊柱炎的诊断主要基于临床表现和影像学检查。在本文中,我们介绍了一名40岁男性患者的病例,该患者因慢性胸中段背痛和颈部活动受限前来就诊。所进行的影像学检查提示骶髂关节融合。本文还强调了在患者慢性症状性主诉情况下炎症标志物升高的情况,这可能有助于早期诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/47ad6a933b70/cureus-0011-00000005723-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/5e689afea890/cureus-0011-00000005723-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/11a3214a9b5d/cureus-0011-00000005723-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/47ad6a933b70/cureus-0011-00000005723-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/5e689afea890/cureus-0011-00000005723-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/11a3214a9b5d/cureus-0011-00000005723-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3168/6823060/47ad6a933b70/cureus-0011-00000005723-i03.jpg

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Front Med (Lausanne). 2019 Aug 7;6:177. doi: 10.3389/fmed.2019.00177. eCollection 2019.
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Cross-sectional study of patients with axial spondyloarthritis fulfilling imaging arm of ASAS classification criteria: baseline clinical characteristics and subset differences in a single-centre cohort.横断面研究满足 ASAS 影像学分类标准的中轴型脊柱关节炎患者:单中心队列的基线临床特征和亚组差异。
BMJ Open. 2019 Apr 2;9(4):e024713. doi: 10.1136/bmjopen-2018-024713.
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miRNA-451a 和 miRNA-125a 在强直性脊柱炎中的表达水平:对疾病诊断、预后和结局的影响。
J Immunol Res. 2020 Dec 28;2020:2180913. doi: 10.1155/2020/2180913. eCollection 2020.
Prevalence of peripheral and extra-articular disease in ankylosing spondylitis versus non-radiographic axial spondyloarthritis: a meta-analysis.
强直性脊柱炎与非放射学中轴型脊柱关节炎外周及关节外疾病的患病率:一项荟萃分析。
Arthritis Res Ther. 2016 Sep 1;18(1):196. doi: 10.1186/s13075-016-1093-z.
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Spinal Fracture in Patients With Ankylosing Spondylitis: Cohort Definition, Distribution of Injuries, and Hospital Outcomes.强直性脊柱炎患者的脊柱骨折:队列定义、损伤分布及医院结局
Spine (Phila Pa 1976). 2016 Feb;41(3):191-6. doi: 10.1097/BRS.0000000000001190.
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American College of Rheumatology/Spondylitis Association of America/Spondyloarthritis Research and Treatment Network 2015 Recommendations for the Treatment of Ankylosing Spondylitis and Nonradiographic Axial Spondyloarthritis.美国风湿病学会/脊柱关节炎协会/脊柱关节炎研究和治疗网络 2015 年强直性脊柱炎和非放射学中轴型脊柱关节炎治疗建议。
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