外周细胞中的阿尔茨海默病机制：前景与挑战。
Alzheimer's disease mechanisms in peripheral cells: Promises and challenges.
作者信息
Trushina Eugenia
机构信息
Department of Neurology, Mayo Clinic, Rochester, MN, USA.
Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, MN, USA.
出版信息
Alzheimers Dement (N Y). 2019 Oct 23;5:652-660. doi: 10.1016/j.trci.2019.06.008. eCollection 2019.
INTRODUCTION
Development of efficacious therapeutic interventions for Alzheimer's disease (AD) is hampered by the lack of understanding early disease mechanisms, biomarkers, and models that mimic complex pathophysiology of human disease.
METHODS
This article aims to assess to what extent peripheral cells recapitulate molecular mechanisms altered in the brain and could be used as translational models for the development of individualized medicine for AD.
RESULTS
Multiple studies suggest that AD is a systemic disorder with an active crosstalk between brain and periphery where multiple pathways altered in the brain cells are also affected in plasma, cerebrospinal fluid, and other peripheral cells of AD patients.
DISCUSSION
Additional studies to validate molecular mechanisms in peripheral cells using advanced system biology techniques and well-characterized cohorts of AD patients together with the development of standardized protocols should be considered to support the application of peripheral cells in AD research.
引言
由于缺乏对早期疾病机制、生物标志物以及模拟人类疾病复杂病理生理学的模型的了解，阿尔茨海默病（AD）有效治疗干预措施的开发受到阻碍。
方法
本文旨在评估外周细胞在多大程度上重现大脑中改变的分子机制，以及能否用作开发AD个性化药物的转化模型。
结果
多项研究表明，AD是一种全身性疾病，大脑与外周之间存在活跃的相互作用，AD患者的血浆、脑脊液和其他外周细胞中，脑细胞中改变的多种途径也受到影响。
讨论
应考虑开展更多研究，使用先进的系统生物学技术和特征明确的AD患者队列来验证外周细胞中的分子机制，并制定标准化方案，以支持外周细胞在AD研究中的应用。
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