腺病毒策略克服先天细胞感染反应。
Adenoviral strategies to overcome innate cellular responses to infection.
机构信息
Department of Microbiology and Immunology, Renaissance School of Medicine, Stony Brook University, NY, USA.
出版信息
FEBS Lett. 2019 Dec;593(24):3484-3495. doi: 10.1002/1873-3468.13680. Epub 2019 Nov 26.
Abstract
Viruses alter host cell processes to optimize their replication cycle. Human adenoviruses (Ad) encode proteins that promote viral macromolecular synthesis and counteract innate and adaptive responses to infection. The focus of this review is on how Ad evades innate cellular responses to infection, including an interferon (IFN) response and a DNA damage response (DDR). Ad blocks the IFN response by inhibiting cytoplasmic signaling pathways and the activation of IFN-stimulated genes (ISGs), as well as the functions of ISG products, such as PML. Ad also inhibits DDR sensors, for instance, the Mre11-Rad50-Nbs1 complex, and DDR effectors like DNA ligase IV. These innate cellular responses impact many different viruses, and studies on Ad have provided broad insight into these areas.
摘要
病毒改变宿主细胞的过程以优化其复制周期。人类腺病毒（Ad）编码的蛋白可促进病毒大分子的合成，并对抗感染引起的固有和适应性反应。本综述的重点是 Ad 如何逃避感染引起的固有细胞反应，包括干扰素（IFN）反应和 DNA 损伤反应（DDR）。Ad 通过抑制细胞质信号通路和 IFN 刺激基因（ISGs）的激活，以及 ISG 产物（如 PML）的功能，来阻断 IFN 反应。Ad 还抑制 DDR 传感器，例如 Mre11-Rad50-Nbs1 复合物，以及 DDR 效应物，如 DNA 连接酶 IV。这些固有细胞反应会影响许多不同的病毒，而对 Ad 的研究为这些领域提供了广泛的认识。
相似文献
1
Adenoviral strategies to overcome innate cellular responses to infection.腺病毒策略克服先天细胞感染反应。
FEBS Lett. 2019 Dec;593(24):3484-3495. doi: 10.1002/1873-3468.13680. Epub 2019 Nov 26.
2
Subversion of host defense mechanisms by adenoviruses.腺病毒对宿主防御机制的破坏
Curr Top Microbiol Immunol. 2002;269:273-318. doi: 10.1007/978-3-642-59421-2_16.
3
En Guard! The Interactions between Adenoviruses and the DNA Damage Response.警惕！腺病毒与 DNA 损伤反应的相互作用。
Viruses. 2020 Sep 7;12(9):996. doi: 10.3390/v12090996.
4
Adenovirus regulates sumoylation of Mre11-Rad50-Nbs1 components through a paralog-specific mechanism.腺病毒通过一种蛋白家族特异性机制调控 Mre11-Rad50-Nbs1 复合物的 SUMO 化修饰。
J Virol. 2012 Sep;86(18):9656-65. doi: 10.1128/JVI.01273-12. Epub 2012 Jun 27.
5
Adenovirus E1B 19-kilodalton protein modulates innate immunity through apoptotic mimicry.腺病毒E1B 19千道尔顿蛋白通过凋亡模拟调节先天免疫。
J Virol. 2014 Mar;88(5):2658-69. doi: 10.1128/JVI.02372-13. Epub 2013 Dec 18.
6
Cellular proteins PML and Daxx mediate an innate antiviral defense antagonized by the adenovirus E4 ORF3 protein.细胞蛋白PML和Daxx介导一种先天性抗病毒防御反应，该反应受到腺病毒E4 ORF3蛋白的拮抗。
J Virol. 2008 Aug;82(15):7325-35. doi: 10.1128/JVI.00723-08. Epub 2008 May 14.
7
How Does Vaccinia Virus Interfere With Interferon?痘苗病毒如何干扰干扰素？
Adv Virus Res. 2018;100:355-378. doi: 10.1016/bs.aivir.2018.01.003. Epub 2018 Feb 16.
8
Human IFIT3 Protein Induces Interferon Signaling and Inhibits Adenovirus Immediate Early Gene Expression.人 IFIT3 蛋白诱导干扰素信号并抑制腺病毒早期基因表达。
mBio. 2021 Dec 21;12(6):e0282921. doi: 10.1128/mBio.02829-21. Epub 2021 Nov 2.
9
The Adenovirus E4-ORF3 Protein Stimulates SUMOylation of General Transcription Factor TFII-I to Direct Proteasomal Degradation.腺病毒E4-ORF3蛋白刺激通用转录因子TFII-I的SUMO化以介导蛋白酶体降解。
mBio. 2016 Jan 26;7(1):e02184-15. doi: 10.1128/mBio.02184-15.
10
Viral and Cellular Genomes Activate Distinct DNA Damage Responses.病毒基因组和细胞基因组激活不同的DNA损伤反应。
Cell. 2015 Aug 27;162(5):987-1002. doi: 10.1016/j.cell.2015.07.058.
引用本文的文献
1
Cellular transcription factor TFII-I represses adenovirus gene expression.细胞转录因子TFII-I抑制腺病毒基因表达。
J Virol. 2025 Jun 17;99(6):e0061825. doi: 10.1128/jvi.00618-25. Epub 2025 May 12.
2
Activated blood-derived human primary T cells support replication of HAdV C5 and virus transmission to polarized human primary epithelial cells.活化的血液来源的人原代T细胞支持人腺病毒C5型的复制以及病毒向极化的人原代上皮细胞的传播。
J Virol. 2025 May 20;99(5):e0182524. doi: 10.1128/jvi.01825-24. Epub 2025 Apr 23.
3
Transient lymphocyte count decrease correlates with oncolytic adenovirus efficacy in humans: mechanistic and biomarker findings from TUNIMO phase I trial.短暂性淋巴细胞计数减少与溶瘤腺病毒在人体中的疗效相关：TUNIMO I期试验的机制和生物标志物研究结果
J Immunother Cancer. 2025 Jan 27;13(1):e010493. doi: 10.1136/jitc-2024-010493.
4
The protein composition of human adenovirus replication compartments.人类腺病毒复制区室的蛋白质组成。
mBio. 2025 Jan 8;16(1):e0214424. doi: 10.1128/mbio.02144-24. Epub 2024 Nov 29.
5
Biomarker screen for efficacy of oncolytic virotherapy in patient-derived pancreatic cancer cultures.用于患者来源的胰腺癌培养物中溶瘤病毒治疗疗效的生物标志物筛选。
EBioMedicine. 2024 Jul;105:105219. doi: 10.1016/j.ebiom.2024.105219. Epub 2024 Jun 27.
6
Molecular insights into type I interferon suppression and enhanced pathogenicity by species B human adenoviruses B7 and B14.解析：这是一段英文，需要将其翻译为中文。译文为：B 型人腺病毒 B7 和 B14 抑制 I 型干扰素及其增强致病性的分子机制。
mBio. 2024 Aug 14;15(8):e0103824. doi: 10.1128/mbio.01038-24. Epub 2024 Jun 28.
7
Differential Contributions of Interferon Classes to Host Inflammatory Responses and Restricting Virus Progeny Production.干扰素类别对宿主炎症反应和限制病毒产物产生的差异贡献。
J Proteome Res. 2024 Aug 2;23(8):3249-3268. doi: 10.1021/acs.jproteome.3c00826. Epub 2024 Apr 2.
8
TCR-transgenic T cells and YB-1-based oncolytic virotherapy improve survival in a preclinical Ewing sarcoma xenograft mouse model.T细胞受体转基因T细胞和基于YB-1的溶瘤病毒疗法可提高临床前尤因肉瘤异种移植小鼠模型的生存率。
Front Immunol. 2024 Jan 22;15:1330868. doi: 10.3389/fimmu.2024.1330868. eCollection 2024.
9
TNIK regulation of interferon signaling and endothelial cell response to virus infection.TNIK对干扰素信号传导及内皮细胞对病毒感染反应的调控
Front Cardiovasc Med. 2024 Jan 9;10:1213428. doi: 10.3389/fcvm.2023.1213428. eCollection 2023.
10
On the Prevalence and Roles of Proteins Undergoing Liquid-Liquid Phase Separation in the Biogenesis of PML-Bodies.在 PML 体生成中经历液-液相分离的蛋白质的流行和作用。
Biomolecules. 2023 Dec 18;13(12):1805. doi: 10.3390/biom13121805.
本文引用的文献
1
Adenovirus Entry: From Infection to Immunity.腺病毒进入：从感染到免疫。
Annu Rev Virol. 2019 Sep 29;6(1):177-197. doi: 10.1146/annurev-virology-092818-015550. Epub 2019 Jul 5.
2
Adenovirus E1B 55-Kilodalton Protein Targets SMARCAL1 for Degradation during Infection and Modulates Cellular DNA Replication.腺病毒 E1B 55 千道尔顿蛋白在感染过程中靶向 SMARCAL1 进行降解，并调节细胞 DNA 复制。
J Virol. 2019 Jun 14;93(13). doi: 10.1128/JVI.00402-19. Print 2019 Jul 1.
3
Mechanism of Adenovirus E4-ORF3-Mediated SUMO Modifications.腺病毒 E4-ORF3 介导的 SUMO 修饰的机制。
mBio. 2019 Feb 26;10(1):e00022-19. doi: 10.1128/mBio.00022-19.
4
SUMO-Mediated Regulation of Nuclear Functions and Signaling Processes.SUMO 介导的核功能和信号转导过程的调节。
Mol Cell. 2018 Aug 2;71(3):409-418. doi: 10.1016/j.molcel.2018.07.027.
5
PML nuclear bodies: from architecture to function.多系统萎缩小体神经元包涵体：从结构到功能。
Curr Opin Cell Biol. 2018 Jun;52:154-161. doi: 10.1016/j.ceb.2018.03.011. Epub 2018 Apr 30.
6
Hacking the Cell: Network Intrusion and Exploitation by Adenovirus E1A.细胞黑客：腺病毒 E1A 的网络入侵与利用。
mBio. 2018 May 1;9(3):e00390-18. doi: 10.1128/mBio.00390-18.
7
The Biology of SUMO-Targeted Ubiquitin Ligases in Drosophila Development, Immunity, and Cancer.果蝇发育、免疫和癌症中靶向SUMO的泛素连接酶的生物学特性
J Dev Biol. 2018 Jan 1;6(1):2. doi: 10.3390/jdb6010002.
8
Degradation of a Novel DNA Damage Response Protein, Tankyrase 1 Binding Protein 1, following Adenovirus Infection.新型 DNA 损伤反应蛋白 Tankyrase 1 结合蛋白 1 在腺病毒感染后的降解。
J Virol. 2018 May 29;92(12). doi: 10.1128/JVI.02034-17. Print 2018 Jun 15.
9
The Adenovirus E1A C Terminus Suppresses a Delayed Antiviral Response and Modulates RAS Signaling.腺病毒 E1A C 末端抑制延迟的抗病毒反应并调节 RAS 信号。
Cell Host Microbe. 2017 Dec 13;22(6):789-800.e5. doi: 10.1016/j.chom.2017.11.008.
10
Key Role of the Scavenger Receptor MARCO in Mediating Adenovirus Infection and Subsequent Innate Responses of Macrophages.清道夫受体MARCO在介导腺病毒感染及随后巨噬细胞的天然免疫反应中的关键作用。
mBio. 2017 Aug 1;8(4):e00670-17. doi: 10.1128/mBio.00670-17.
Zotero 插件