加速寻找旨在延长人类健康寿命的干预措施：流行病学的作用。
Accelerating the Search for Interventions Aimed at Expanding the Health Span in Humans: The Role of Epidemiology.
机构信息
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pennsylvania.
Department of Geriatric Medicine, School of Medicine, University of Pittsburgh, Pennsylvania.
出版信息
J Gerontol A Biol Sci Med Sci. 2020 Jan 1;75(1):77-86. doi: 10.1093/gerona/glz230.
Abstract
BACKGROUND
Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow.
METHODS
Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging.
RESULTS
Epidemiologic studies play a vital role to progress in this field, particularly in evaluating new risk factors and measures of biologic aging that may influence health span, as well as developing relevant outcome measures that are robust and relevant for older individuals.
CONCLUSIONS
Appropriately designed epidemiological studies are needed to identify targets for intervention and to inform study design and sample size estimates for future clinical trials designed to promote health span.
摘要
背景
基础科学和临床科学的大量研究表明，衰老的生物学机制与晚年疾病和残疾的发展有因果关系。在动物模型中，衰老生物学机制的调节可以延长寿命和健康寿命，但向人类的转化进展缓慢。
方法
对国家老龄化研究所的内部研究计划主办的 2018-2019 年衰老流行病学研讨会的会议记录进行总结。
结果
流行病学研究在该领域的进展中起着至关重要的作用，特别是在评估可能影响健康寿命的新的风险因素和生物衰老测量方法，以及开发对老年人健壮且相关的相关结果测量方法方面。
结论
需要进行适当设计的流行病学研究，以确定干预目标，并为未来旨在促进健康寿命的临床试验提供研究设计和样本量估计的信息。
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