肾盂移行细胞癌：通过流式细胞术研究细胞核脱氧核糖核酸倍性

Transitional cell carcinoma of the renal pelvis: nuclear deoxyribonucleic acid ploidy studied by flow cytometry.

作者信息

Blute M L, Tsushima K, Farrow G M, Therneau T M, Lieber M M

机构信息

Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.

出版信息

J Urol. 1988 Nov;140(5):944-9. doi: 10.1016/s0022-5347(17)41894-5.

DOI:10.1016/s0022-5347(17)41894-5

PMID:3172363

Abstract

Nuclear deoxyribonucleic acid ploidy analysis by flow cytometry was performed successfully on 109 formalin-fixed paraffin-embedded tissue specimens of transitional cell carcinoma of the renal pelvis. Tumor tissues were from patients who were operated upon between 1960 and 1975, so that long-term clinical followup was available. There were good correlations among deoxyribonucleic acid ploidy pattern and histological grade, pathological stage and clinical outcome. For high grade, high stage tumors deoxyribonucleic acid ploidy pattern provided no additional prognostically important information. However, for the more common low grade, low stage tumors the occasional detection of deoxyribonucleic acid aneuploidy patterns identified an important subgroup of patients who experienced significantly poorer survival.

摘要

通过流式细胞术对109例肾盂移行细胞癌的福尔马林固定石蜡包埋组织标本成功进行了细胞核脱氧核糖核酸倍体分析。肿瘤组织来自1960年至1975年间接受手术的患者，因此可进行长期临床随访。脱氧核糖核酸倍体模式与组织学分级、病理分期及临床结果之间存在良好的相关性。对于高级别、高分期肿瘤，脱氧核糖核酸倍体模式未提供额外的重要预后信息。然而，对于更常见的低级别、低分期肿瘤，偶尔检测到的脱氧核糖核酸非整倍体模式识别出了一组生存情况明显较差的重要亚组患者。