Lee Jin Gu, Park Moo Suk, Jeong Su Jin, Kim Song Yee, Na Sungwon, Kim Jeongmin, Paik Hyo Chae
Department of Thoracic and Cardiovascular Surgery, Yonsei University College of Medicine, Seoul, Korea.
Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
Acute Crit Care. 2018 Nov;33(4):197-205. doi: 10.4266/acc.2018.00367. Epub 2018 Nov 30.
Lung transplantation is widely accepted as the only viable treatment option for patients with end-stage lung disease. However, the imbalance between the number of suitable donor lungs available and the number of possible candidates often results in intensive care unit (ICU) admission for the latter. In the ICU setting, critical care is essential to keep these patients alive and to successfully bridge to lung transplantation. Proper management in the ICU is also one of the key factors supporting long-term success following transplantation. Critical care includes the provision of respiratory support such as mechanical ventilation (MV) and extracorporeal life support (ECLS). Accordingly, a working knowledge of the common critical care issues related to these unique patients and the early recognition and management of problems that arise before and after transplantation in the ICU setting are crucial for long-term success. In this review, we discuss the management and selection of candidates for lung transplantation as well as existing respiratory support strategies that involve MV and ECLS in the ICU setting.
肺移植被广泛认为是终末期肺病患者唯一可行的治疗选择。然而,可用的合适供肺数量与潜在候选者数量之间的不平衡,常常导致后者入住重症监护病房(ICU)。在ICU环境中,重症监护对于维持这些患者的生命以及成功过渡到肺移植至关重要。ICU中的恰当管理也是支持移植后长期成功的关键因素之一。重症监护包括提供呼吸支持,如机械通气(MV)和体外生命支持(ECLS)。因此,了解与这些特殊患者相关的常见重症监护问题,以及在ICU环境中对移植前后出现的问题进行早期识别和管理,对于长期成功至关重要。在本综述中,我们讨论了肺移植候选者的管理与选择,以及ICU环境中涉及MV和ECLS的现有呼吸支持策略。