来自夹竹桃科倒吊笔属植物的新型伊博格型吲哚生物碱。

New Iboga-Type Indole Alkaloids from Tabernaemontana divaricata.

作者信息

Li Xiang-Mei, Jiang Xian-Jun, Wei Guo-Zhu, Ren Li-Hua, Wang Li-Xia, Cheng Xue-Lian, Wang Fei

机构信息

BioBioPha Co., Ltd., Kunming, 650201, People's Republic of China.

Reference Substance Branch, National Engineering Research Center for Modernization of Traditional Chinese Medicine, Kunming, 650201, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2019 Dec;9(6):425-429. doi: 10.1007/s13659-019-00226-z. Epub 2019 Nov 14.

DOI:10.1007/s13659-019-00226-z

PMID:31724098

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6872691/

Abstract

Two hitherto unknown iboga-type indole alkaloids, namely (3R)-7,19-di-epi-3-methoxytabernoxidine (1) and (3R,19R)-19-hydroxy-3-(2-oxopropyl)voacangine (2), together with eight known alkaloids (3-10), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were established on the basis of spectroscopic data interpretation, single crystal X-ray diffraction analysis and circular dichroism spectrum.

摘要

从海南狗牙花的嫩枝和叶子中分离出两种迄今未知的伊博格型吲哚生物碱，即(3R)-7,19-二表-3-甲氧基狗牙花定碱(1)和(3R,19R)-19-羟基-3-(2-氧代丙基)沃坎京碱(2)，以及八种已知生物碱(3-10)。它们的结构是基于光谱数据解析、单晶X射线衍射分析和圆二色光谱确定的。