布西基内斯A - E，来自两种布西戈尼亚属植物的新生物碱：狭叶布西戈尼亚和湄公河布西戈尼亚。
Bousmekines A-E, New Alkaloids from Two Bousigonia Species: B.angustifolia and B. mekongensis.
作者信息
Huo Zong-Qing, Zhao Qian, Zhu Wen-Tao, Hao Xiao-Jiang, Zhang Yu
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China.
出版信息
Nat Prod Bioprospect. 2021 Apr;11(2):207-213. doi: 10.1007/s13659-020-00278-6. Epub 2020 Nov 3.
Four new monoterpenoid indole alkaloids, bousmekines A-D (1-4), and one new pyranopyridine alkaloid, bousmekine E (5), were isolated from the twigs and leaves of Bousigonia angustifolia and Bousigonia mekongensis. Their structures including absolute configurations were elucidated by a combination of MS, NMR, ECD calculation, and single-crystal X-ray diffraction analysis. Compound 2 was an eburnea-type MIAs characterized by a rare chlorine atom while 5 possessed a novel pyranopyridine moiety. Their cytotoxicities against several human cancer cell lines were evaluated and compound 1 exhibited significant cytotoxicity with IC values of 0.8-7.4 μM.
从狭叶布西戈尼亚和湄公河布西戈尼亚的嫩枝和叶子中分离出四种新的单萜吲哚生物碱，即布西美碱A-D（1-4），以及一种新的吡喃吡啶生物碱，布西美碱E（5）。通过质谱、核磁共振、电子圆二色光谱计算和单晶X射线衍射分析相结合的方法阐明了它们的结构，包括绝对构型。化合物2是一种埃布内亚型单萜吲哚生物碱，其特征在于含有一个罕见的氯原子，而化合物5具有一个新颖的吡喃吡啶部分。评估了它们对几种人类癌细胞系的细胞毒性，化合物1表现出显著的细胞毒性，IC值为0.8-7.4 μM。
Zotero 插件