Van Beek T A, Verpoorte R, Svendsen A B, Fokkens R
J Nat Prod. 1985 May-Jun;48(3):400-23. doi: 10.1021/np50039a008.
From Tabernaemontana chippii root bark, forty-five alkaloids were isolated; thirty-four were fully characterized by means of their spectral data and/or co-tlc; eight alkaloids were new, four of them being 3-hydroxy derivatives of known dimeric voacamine type alkaloids. Most of the twenty-six known alkaloids belonged to the corynanthean, ibogan, or bisindole classes. The structures of eleven other alkaloids--all minor--were only partially elucidated, most of them being new alkaloids. All the dimeric alkaloids were shown to possess strong antimicrobial activity against gram-positive bacteria and moderate to weak activity against gram-negative bacteria.
从奇氏狗牙花根皮中分离出45种生物碱；其中34种通过光谱数据和/或共薄层色谱法得到了完全表征；8种生物碱是新的，其中4种是已知二聚体沃卡明型生物碱的3-羟基衍生物。26种已知生物碱中的大多数属于可里那斯类、伊波加类或双吲哚类。其他11种生物碱——均为微量生物碱——的结构仅得到部分阐明，其中大多数是新生物碱。所有二聚体生物碱对革兰氏阳性菌均表现出较强的抗菌活性，对革兰氏阴性菌表现出中度至弱的活性。
