右酮洛芬治疗偏头痛发作的疗效：一项随机对照研究的荟萃分析。
The efficacy of dexketoprofen for migraine attack: A meta-analysis of randomized controlled studies.
作者信息
Yang Baohua, Xu Zhili, Chen Linglong, Chen Xinguo, Xie Yuequn
机构信息
Department of Emergency, Wenzhou People's Hospital, The Wenzhou Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou Maternal and Child Health Care Hospital, Wenzhou, Zhejiang 325000, P.R. China.
出版信息
Medicine (Baltimore). 2019 Nov;98(46):e17734. doi: 10.1097/MD.0000000000017734.
BACKGROUND
The efficacy of dexketoprofen for migraine attack remains controversial. We conduct a systematic review and meta-analysis to explore the influence of dexketoprofen supplementation versus placebo on pain control in migraine attack patients.
METHODS
We search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through March 2019 for randomized controlled trials (RCTs) assessing the effect of dexketoprofen supplementation versus placebo on pain control for migraine attack patients. This meta-analysis is performed using the random-effect model.
RESULTS
Five RCTs involving 794 patients are included in the meta-analysis. Overall, compared with control group for migraine attack, dexketoprofen supplementation is associated with substantially increased pain free at 2 hours (RR = 1.90; 95% CI = 1.43-2.53; P < .0001), pain free at 48 hours (RR = 1.63; 95% CI = 1.07-2.49; P = .02), good or excellent treatment (RR = 1.48; 95% CI = 1.24-1.78; P < .0001) and pain relief at 2 hours (RR = 1.80; 95% CI = 1.17-2.77; P = .007), as well as reduced need for rescue drug (RR = 0.64; 95% CI = 0.43-0.94; P = .02), with no significant increase in adverse events (RR = 1.51; 95% CI = 0.87-2.62; P = .14).
CONCLUSION
Dexketoprofen supplementation benefits to improve pain control at 48 hours and reduce the need for rescue drug in migraine attack patients.
背景
右酮洛芬用于偏头痛发作的疗效仍存在争议。我们进行了一项系统评价和荟萃分析，以探讨补充右酮洛芬与安慰剂相比对偏头痛发作患者疼痛控制的影响。
方法
我们检索了截至2019年3月的PubMed、EMbase、Web of science、EBSCO和Cochrane图书馆数据库，以查找评估补充右酮洛芬与安慰剂相比对偏头痛发作患者疼痛控制效果的随机对照试验（RCT）。本荟萃分析采用随机效应模型进行。
结果
五项涉及794例患者的RCT纳入了荟萃分析。总体而言，与偏头痛发作对照组相比，补充右酮洛芬与2小时时无痛率大幅增加（RR = 1.90；95%CI = 1.43 - 2.53；P <.0001）、48小时时无痛率（RR = 1.63；95%CI = 1.07 - 2.49；P = 0.02）、良好或优秀治疗率（RR = 1.48；95%CI = 1.24 - 1.78；P <.0001）以及2小时时疼痛缓解率（RR = 1.80；95%CI = 1.17 - 2.77；P = 0.007）相关，同时救援药物需求减少（RR = 0.64；95%CI = 0.43 - 0.94；P = 0.02），不良事件无显著增加（RR = 1.51；95%CI = 0.87 - 2.62；P = 0.14）。
结论
补充右酮洛芬有利于改善偏头痛发作患者48小时时的疼痛控制并减少救援药物需求。
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