姜治疗偏头痛的疗效：一项随机对照研究的荟萃分析。

The efficacy of ginger for the treatment of migraine: A meta-analysis of randomized controlled studies.

机构信息

Department of Neurology, Chongqing General Hospital, University of Chinese Academy of Science, Chongqing, PR China; Chongqing key laboratory of Neurodegenerative Disease, Chongqing general hospital, Chongqing, PR China.

出版信息

Am J Emerg Med. 2021 Aug;46:567-571. doi: 10.1016/j.ajem.2020.11.030. Epub 2020 Nov 17.

DOI:10.1016/j.ajem.2020.11.030

PMID:33293189

Abstract

INTRODUCTION

The efficacy of ginger for migraine remains controversial. We conduct a systematic review and meta-analysis to explore the influence of ginger versus placebo on treatment in migraine patients.

METHODS

We have searched PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through September 2020 for randomized controlled trials (RCTs) assessing the effect of ginger versus placebo on treatment efficacy in migraine patients. This meta-analysis is performed using the random-effect model.

RESULTS

Three RCTs are included in the meta-analysis. Overall, compared with control group in migraine patients, ginger treatment is associated with substantially improved pain free at 2 h (RR = 1.79; 95% CI = 1.04-3.09; P = 0.04) and reduced pain scores at 2 h (MD = -1.27; 95% CI = -1.46 to -1.07; P < 0.00001), but reveals no obvious impact on treatment response (RR = 2.04; 95% CI = 0.35-11.94; P = 0.43) or total adverse events (RR = 0.80; 95% CI = 0.46-1.41; P = 0.44). The incidence of nausea and vomiting is obviously lower in ginger group than that in control group.

CONCLUSIONS

Ginger is safe and effective in treating migraine patients with pain outcomes assessed at 2 h.

摘要

简介

姜治疗偏头痛的疗效仍存在争议。我们进行了系统评价和荟萃分析，以探讨姜与安慰剂对偏头痛患者治疗的影响。

方法

我们通过检索 PubMed、EMbase、Web of science、EBSCO 和 Cochrane 图书馆数据库，截至 2020 年 9 月，查找评估姜与安慰剂对偏头痛患者治疗效果的随机对照试验（RCT）。本荟萃分析采用随机效应模型进行。

结果

共有 3 项 RCT 纳入荟萃分析。总体而言，与对照组相比，姜治疗组在 2 小时时无疼痛的患者比例显著增加（RR=1.79；95%CI=1.04-3.09；P=0.04），2 小时时疼痛评分降低（MD=-1.27；95%CI=-1.46 至-1.07；P<0.00001），但对治疗反应（RR=2.04；95%CI=0.35-11.94；P=0.43）或总不良反应（RR=0.80；95%CI=0.46-1.41；P=0.44）无明显影响。与对照组相比，姜治疗组恶心和呕吐的发生率明显降低。