Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Vienna Health Association, Landstrasse Hospital/Favoriten Hospital, 1030 Vienna, Austria.
Int J Mol Sci. 2022 Sep 5;23(17):10152. doi: 10.3390/ijms231710152.
Objective: To compare total retinal oxygen extraction between patients with primary open-angle glaucoma (POAG) and healthy control subjects. Design: A prospective, single-center, cross-sectional, case−control study performed at the Medical University of Vienna. Subjects: Forty patients with POAG and 40 age- and sex-matched control subjects. Methods: Total retinal blood flow was measured using Doppler optical coherence tomography (OCT). Retinal arterial and venous oxygen saturation was measured using reflectance spectroscopy. From these parameters, oxygen content in the retinal arterial and venous circulation as well as total retinal oxygen extraction were calculated. Results: Total retinal blood flow was lower in POAG (25.2 ± 6.7 µL/min) as compared to healthy control subjects (35.6 ± 8.3 µL/min, p < 0.001). Retinal arterial oxygen content was not different between the two groups (0.18 ± 0.01 mL(O2)/mL in both groups, p < 0.761), but retinal venous oxygen content was higher in POAG (0.15 ± 0.01 mL(O2)/mL) than in healthy controls (0.14 ± 0.01 mL(O2)/mL p < 0.001). Accordingly, retinal oxygen extraction was reduced in POAG (0.8 ± 0.3 µL(O2)/min as compared to healthy controls: 1.4 ± 0.4 µL(O2)/min, p < 0.001). There was a significant association between total retinal blood flow and total retinal oxygen extraction with measures of structural and functional damage (p < 0.001 each). Conclusions: This study indicates that POAG is associated with a reduction in total retinal oxygen extraction linked to structural and functional damage of the disease. Since the technology is non-invasive, it allows for longitudinal studies investigating to which degree low retinal oxygen extraction is linked to the progression of the disease.
比较原发性开角型青光眼（POAG）患者与健康对照者之间的总视网膜氧摄取量。
在维也纳医科大学进行的前瞻性、单中心、横断面、病例对照研究。
40 例 POAG 患者和 40 例年龄和性别匹配的对照者。
使用多普勒光学相干断层扫描（OCT）测量总视网膜血流。使用反射光谱法测量视网膜动脉和静脉血氧饱和度。根据这些参数，计算视网膜动脉和静脉循环中的氧含量以及总视网膜氧摄取量。
POAG 患者的总视网膜血流（25.2 ± 6.7 µL/min）低于健康对照组（35.6 ± 8.3 µL/min，p < 0.001）。两组间视网膜动脉氧含量无差异（两组均为 0.18 ± 0.01 mL(O2)/mL，p < 0.761），但 POAG 患者的视网膜静脉氧含量较高（0.15 ± 0.01 mL(O2)/mL），而健康对照组（0.14 ± 0.01 mL(O2)/mL，p < 0.001）。因此，POAG 患者的视网膜氧摄取量降低（0.8 ± 0.3 µL(O2)/min，与健康对照组相比：1.4 ± 0.4 µL(O2)/min，p < 0.001）。总视网膜血流与总视网膜氧摄取量与结构和功能损伤的测量值之间存在显著相关性（p < 0.001 ）。
本研究表明，POAG 与总视网膜氧摄取量降低有关，这与疾病的结构和功能损伤有关。由于该技术是非侵入性的，因此可以进行纵向研究，以确定低视网膜氧摄取量与疾病进展的程度。
