在大鼠模型中，围手术期短期使用帕瑞昔布对骨干骨折愈合无害。
Short-term perioperative parecoxib is not detrimental to shaft fracture healing in a rat model.
作者信息
Hjorthaug G A, Søreide E, Nordsletten L, Madsen J E, Reinholt F P, Niratisairak S, Dimmen S
机构信息
Department of Orthopedic Surgery, Martina Hansens Hospital, Sandvika, Norway; Institute of Clinical Medicine, Faculty of Medicine, University of Oslo (UIO), Oslo, Norway; Experimental Orthopedic Research, Institute for Surgical Research, Oslo University Hospital (OUS), Oslo, Norway.
Division of Orthopedic Surgery, OUS, Oslo, Norway; Institute of Clinical Medicine, Faculty of Medicine, UIO, Oslo, Norway; Experimental Orthopedic Research, Institute for Surgical Research, OUS, Oslo, Norway.
出版信息
Bone Joint Res. 2019 Nov 2;8(10):472-480. doi: 10.1302/2046-3758.810.BJR-2018-0341.R1. eCollection 2019 Oct.
OBJECTIVES
Experimental studies indicate that non-steroidal anti-inflammatory drugs (NSAIDs) may have negative effects on fracture healing. This study aimed to assess the effect of immediate and delayed short-term administration of clinically relevant parecoxib doses and timing on fracture healing using an established animal fracture model.
METHODS
A standardized closed tibia shaft fracture was induced and stabilized by reamed intramedullary nailing in 66 Wistar rats. A 'parecoxib immediate' (Pi) group received parecoxib (3.2 mg/kg bodyweight twice per day) on days 0, 1, and 2. A 'parecoxib delayed' (Pd) group received the same dose of parecoxib on days 3, 4, and 5. A control group received saline only. Fracture healing was evaluated by biomechanical tests, histomorphometry, and dual-energy x-ray absorptiometry (DXA) at four weeks.
RESULTS
For ultimate bending moment, the median ratio between fractured and non-fractured tibia was 0.61 (interquartile range (IQR) 0.45 to 0.82) in the Pi group, 0.44 (IQR 0.42 to 0.52) in the Pd group, and 0.50 (IQR 0.41 to 0.75) in the control group (n = 44; p = 0.068). There were no differences between the groups for stiffness, energy, deflection, callus diameter, DXA measurements (n = 64), histomorphometrically osteoid/bone ratio, or callus area (n = 20).
CONCLUSION
This study demonstrates no negative effect of immediate or delayed short-term administration of parecoxib on diaphyseal fracture healing in rats.: G. A. Hjorthaug, E. Søreide, L. Nordsletten, J. E. Madsen, F. P. Reinholt, S. Niratisairak, S. Dimmen. Short-term perioperative parecoxib is not detrimental to shaft fracture healing in a rat model. 2019;8:472-480. DOI: 10.1302/2046-3758.810.BJR-2018-0341.R1.
目的
实验研究表明，非甾体类抗炎药（NSAIDs）可能对骨折愈合产生负面影响。本研究旨在使用已建立的动物骨折模型，评估临床相关剂量的帕瑞昔布即刻和延迟短期给药及其给药时间对骨折愈合的影响。
方法
通过扩髓髓内钉固定诱导并稳定66只Wistar大鼠的标准化闭合性胫骨干骨折。“帕瑞昔布即刻”（Pi）组在第0、1和2天接受帕瑞昔布（3.2mg/kg体重，每天两次）。“帕瑞昔布延迟”（Pd）组在第3、4和5天接受相同剂量的帕瑞昔布。对照组仅接受生理盐水。四周时通过生物力学测试、组织形态计量学和双能X线吸收法（DXA）评估骨折愈合情况。
结果
对于极限弯矩，Pi组骨折胫骨与未骨折胫骨的中位数比值为0.61（四分位间距（IQR）0.45至0.8），Pd组为0.44（IQR 0.42至0.52），对照组为0.50（IQR 0.41至0.75）（n = 44；p = 0.068）。各组之间在刚度、能量、挠度、骨痂直径、DXA测量值（n = 64）、组织形态计量学上的类骨质/骨比值或骨痂面积（n = 20）方面无差异。
结论
本研究表明，即刻或延迟短期给予帕瑞昔布对大鼠骨干骨折愈合无负面影响。：G.A. Hjorthaug、E. Søreide、L. Nordsletten、J.E. Madsen、F.P. Reinholt、S. Niratisairak、S. Dimmen。围手术期短期使用帕瑞昔布对大鼠模型骨干骨折愈合无害。2019；8：472 - 480。DOI：10.1302/2046 - 3758.810.BJR - 2018 - 0341.R1。
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